Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …

Objective Neuropathological studies have demonstrated that cerebrovascular disease and
Alzheimer disease (AD) pathology frequently co‐occur in older adults. The extent to which …

Importance β-Amyloid (Aβ) deposition and vascular brain injury (VBI) frequently co-occur
and are both associated with cognitive decline in aging. Determining whether a direct …

Objective: To investigate the vascular contribution to longitudinal changes in Alzheimer
disease (AD) biomarkers. Methods: The Alzheimer's Disease Neuroimaging Initiative is a …

Objective To investigate the associations between age, vascular health, and Alzheimer
disease (AD) imaging biomarkers in an elderly sample. Methods We identified 430 …

Importance Identifying risk factors for increased β-amyloid (Aβ) deposition is important for
targeting individuals most at risk for developing Alzheimer disease and informing clinical …

Our primary objective was to investigate a biomarker driven model for the interrelationships
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …

Importance Midlife vascular risk factors have been associated with late-life dementia.
Whether these risk factors directly contribute to brain amyloid deposition is less well …

We examined the relationships of antemortem vascular risk factors to postmortem
cerebrovascular and Alzheimer's disease (AD) pathologies. Eighty-four AD patients …

Importance In the absence of disease-modifying therapies for Alzheimer disease, there is a
critical need to identify modifiable risk factors that may delay the progression of Alzheimer …