Importance Vascular risk factors have been associated with cognitive decline. Midlife
exposure to these factors may be most important in conferring late-life risk of cognitive …

Background and Purpose—This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …

This study assessed relationships among white matter hyperintensities (WMH),
cerebrospinal fluid (CSF), Alzheimer's disease (AD) pathology markers, and brain volume …

Vascular and neurodegenerative disease commonly cooccur in older persons. We review
findings from the Rush Religious Orders Study and Memory and Aging Project. Both studies …

Background Vascular factors including medical history (heart disease, stroke, diabetes, and
hypertension), smoking, and prediagnosis blood lipid measurements (cholesterol: total, high …

Importance Criteria for preclinical Alzheimer disease (AD) propose β-amyloid (Aβ) plaques
to initiate neurodegeneration within AD-affected regions. However, some cognitively normal …

Importance Midlife vascular risk burden is associated with late-life dementia. Less is known
about if and how risk exposure in early adulthood influences late-life brain health. Objective …

Objective To investigate the multifactorial processes underlying cognitive aging based on
the hypothesis that multiple causal pathways and mechanisms (amyloid, vascular, and …

Accumulating data suggest that cerebrovascular disease contributes to Alzheimer's disease
pathophysiology and progression toward dementia. Cerebral amyloid angiopathy is a form …

Introduction Vascular factors increase the risk of Alzheimer's disease (AD). We investigated
the associations between such factors, longitudinal AD cerebrospinal fluid biomarkers, and …