Objective Although it is now accepted that asymptomatic cerebral infarcts are an important
cause of dementia in the elderly, the relationship between atherosclerosis per se and …

An increasing number of studies suggest a vascular contribution to Alzheimer's disease
(AD). One major question these findings raise is whether vascular disease enhances the …

Alzheimer's disease and cerebrovascular disease are two illnesses common to the elderly.
Conventional wisdom has sought to separately describe and treat these two diseases …

Importance Because deposition of cerebral β-amyloid (Aβ) seems to be a key initiating event
in Alzheimer disease (AD), factors associated with increased deposition are of great interest …

Age is the strongest risk factor for brain degeneration whether it results from vascular or
neurodegenerative mechanisms or both. To evaluate the current views on the impact of …

Importance The Anti-Amyloid Treatment in Asymptomatic Alzheimer disease (A4) Study is an
ongoing prevention trial in clinically normal older individuals with evidence of elevated brain …

Objective To investigate the effects of lifestyle and vascular-related risk factors for
Alzheimer's disease (AD) on in vivo MRI-based brain atrophy in asymptomatic young to …

Abstract Background African Americans have been reported to have a higher prevalence of
Alzheimer's disease (AD) than Caucasians, but etiology-specific AD biomarkers have not …

BACKGROUND: Strokes, vascular risk factors, and apolipoprotein E (APOE) genotype are
associated with cognitive decline in the elderly, but definitive evidence that these affect …

Epidemiologic evidence and postmortem studies of cerebral amyloid angiopathy suggest
that vascular dysfunction may play an important role in the pathogenesis of Alzheimer's …