[HTML][HTML] Genome mining reveals novel biosynthetic gene clusters in entomopathogenic bacteria

W Meesil, P Muangpat, S Sitthisak, T Rattanarojpong… - Scientific Reports, 2023 - nature.com
The discovery of novel bioactive compounds produced by microorganisms holds significant
potential for the development of therapeutics and agrochemicals. In this study, we conducted …

[HTML][HTML] Genome analysis of secondary metabolite‑biosynthetic gene clusters of Photorhabdus akhurstii subsp. akhurstii and its antibacterial activity against antibiotic …

P Muangpat, W Meesil, J Ngoenkam, Y Teethaisong… - Plos one, 2022 - journals.plos.org
Xenorhabdus and Photorhabdus can produce a variety of secondary metabolites with broad
spectrum bioactivity against microorganisms. We investigated the antibacterial activity of …

[HTML][HTML] Mining Biosynthetic Gene Clusters of Pseudomonas vancouverensis Utilizing Whole Genome Sequencing

P Tamang, A Upadhaya, P Paudel, K Meepagala… - Microorganisms, 2024 - mdpi.com
Natural product (NP)-based pesticides have emerged as a compelling alternative to
traditional chemical fungicides, attracting substantial attention within the agrochemical …

Natural product discovery through microbial genome mining

E Kenshole, M Herisse, M Michael, SJ Pidot - Current Opinion in Chemical …, 2021 - Elsevier
The advent of the genomic era has opened up enormous possibilities for the discovery of
new natural products. Also known as specialized metabolites, these compounds produced …

Comprehensive curation and analysis of fungal biosynthetic gene clusters of published natural products

YF Li, KJS Tsai, CJB Harvey, JJ Li, BE Ary… - Fungal Genetics and …, 2016 - Elsevier
Microorganisms produce a wide range of natural products (NPs) with clinically and
agriculturally relevant biological activities. In bacteria and fungi, genes encoding successive …

[HTML][HTML] High-Throughput Mining of Novel Compounds from Known Microbes: A Boost to Natural Product Screening

SN Meena, A Wajs-Bonikowska, S Girawale, M Imran… - Molecules, 2024 - mdpi.com
Advanced techniques can accelerate the pace of natural product discovery from microbes,
which has been lagging behind the drug discovery era. Therefore, the present review article …

Genome-based bioprospecting of microbes for new therapeutics

SB Zotchev, ON Sekurova, L Katz - Current opinion in biotechnology, 2012 - Elsevier
Bioprospecting of natural sources for new medicines has a long and successful history,
exemplified by the fact that over 50% of all drugs currently on the market are either derived …

[HTML][HTML] Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi

PN Tran, MR Yen, CY Chiang, HC Lin… - Applied microbiology and …, 2019 - Springer
Secondary metabolites (SM) produced by fungi and bacteria have long been of exceptional
interest owing to their unique biomedical ramifications. The traditional discovery of new …

Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

BO Bachmann, SG Van Lanen… - Journal of industrial …, 2014 - academic.oup.com
Microbial genome mining is a rapidly developing approach to discover new and novel
secondary metabolites for drug discovery. Many advances have been made in the past …

New keys to unlock the treasure trove of microbial natural products

DW Udwary, H Otani, NJ Mouncey - Nature Reviews Microbiology, 2021 - nature.com
New keys to unlock the treasure trove of microbial natural products | Nature Reviews Microbiology
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