Blood-based protein biomarkers for the management of traumatic brain injuries in adults presenting to emergency departments with mild brain injury: a living …

S Mondello, A Sorinola, E Czeiter, Z Vámos… - Journal of …, 2021 - liebertpub.com
Accurate diagnosis of traumatic brain injury (TBI) is critical to effective management and
intervention, but can be challenging in patients with mild TBI. A substantial number of …

Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics

E Kövesdi, J Lückl, P Bukovics, O Farkas, J Pál… - Acta …, 2010 - Springer
Purpose This review summarizes protein biomarkers in mild and severe traumatic brain
injury in adults and children and presents a strategy for conducting rationally designed …

Blood biomarkers on admission in acute traumatic brain injury: relations to severity, CT findings and care path in the CENTER-TBI study

E Czeiter, K Amrein, BY Gravesteijn, F Lecky… - …, 2020 - thelancet.com
Background Serum biomarkers may inform and improve care in traumatic brain injury (TBI).
We aimed to correlate serum biomarkers with clinical severity, care path and imaging …

A serum protein biomarker panel improves outcome prediction in human traumatic brain injury

E Thelin, F Al Nimer, A Frostell, H Zetterberg… - Journal of …, 2019 - liebertpub.com
Brain-enriched protein biomarkers of tissue fate are being introduced clinically to aid in
traumatic brain injury (TBI) management. The aim of this study was to determine how …

Blood biomarkers for traumatic brain injury: a quantitative assessment of diagnostic and prognostic accuracy

ZS Gan, SC Stein, R Swanson, S Guan… - Frontiers in …, 2019 - frontiersin.org
Blood biomarkers have been explored for their potential to provide objective measures in
the assessment of traumatic brain injury (TBI). However, it is not clear which biomarkers are …

Blood biomarkers in moderate-to-severe traumatic brain injury: potential utility of a multi-marker approach in characterizing outcome

AP Di Battista, JE Buonora, SG Rhind… - Frontiers in …, 2015 - frontiersin.org
Background Blood biomarkers are valuable tools for elucidating complex cellular and
molecular mechanisms underlying traumatic brain injury (TBI). Profiling distinct classes of …

A blood-based biomarker panel to risk-stratify mild traumatic brain injury

R Sharma, A Rosenberg, ER Bennett, DT Laskowitz… - PloS one, 2017 - journals.plos.org
Mild traumatic brain injury (TBI) accounts for the vast majority of the nearly two million brain
injuries suffered in the United States each year. Mild TBI is commonly classified as …

Incremental prognostic value of acute serum biomarkers for functional outcome after traumatic brain injury (CENTER-TBI): an observational cohort study

IRAR Helmrich, E Czeiter, K Amrein, A Büki… - The Lancet …, 2022 - thelancet.com
Background Several studies have reported an association between serum biomarker values
and functional outcome following traumatic brain injury. We aimed to examine the …

Biomarkers for the clinical differential diagnosis in traumatic brain injury—a systematic review

S Yokobori, K Hosein, S Burks, I Sharma… - CNS neuroscience & …, 2013 - Wiley Online Library
Rapid triage and decision‐making in the treatment of traumatic brain injury (TBI) present
challenging dilemma in “resource poor” environments such as the battlefield and developing …

Blood-based biomarkers for traumatic brain injury: evaluation of research approaches, available methods and potential utility from the clinician and clinical laboratory …

FG Strathmann, S Schulte, K Goerl, DJ Petron - Clinical biochemistry, 2014 - Elsevier
Blood-based biomarkers for traumatic brain injury (TBI) have been investigated and
proposed for decades, yet the current clinical assessment of TBI is largely based on clinical …