A large-scale whole-genome comparison shows that experimental evolution in response to antibiotics predicts changes in naturally evolved clinical Pseudomonas …
SJT Wardell, A Rehman, LW Martin… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide range of acute
and chronic infections. An increasing number of isolates have mutations that make them …
and chronic infections. An increasing number of isolates have mutations that make them …
The Versatile Mutational Resistome of Pseudomonas aeruginosa
C López-Causapé, G Cabot… - Frontiers in …, 2018 - frontiersin.org
One of the most striking features of Pseudomonas aeruginosa is its outstanding capacity for
developing antimicrobial resistance to nearly all available antipseudomonal agents through …
developing antimicrobial resistance to nearly all available antipseudomonal agents through …
Antibiotic resistance in Pseudomonas aeruginosa and adaptation to complex dynamic environments
Antibiotic resistance has become a serious threat to human health (WHO Antibacterial
Agents in Clinical Development: an Analysis of the Antibacterial Clinical Development …
Agents in Clinical Development: an Analysis of the Antibacterial Clinical Development …
Transcriptome profiling of antimicrobial resistance in Pseudomonas aeruginosa
A Khaledi, M Schniederjans, S Pohl… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Emerging resistance to antimicrobials and the lack of new antibiotic drug candidates
underscore the need for optimization of current diagnostics and therapies to diminish the …
underscore the need for optimization of current diagnostics and therapies to diminish the …
Virulence Characteristics and an Action Mode of Antibiotic Resistance in Multidrug-Resistant Pseudomonas aeruginosa
W Hwang, SS Yoon - Scientific reports, 2019 - nature.com
Pseudomonas aeruginosa displays intrinsic resistance to many antibiotics and known to
acquire actively genetic mutations for further resistance. In this study, we attempted to …
acquire actively genetic mutations for further resistance. In this study, we attempted to …
Genomewide Identification of Genetic Determinants of Antimicrobial Drug Resistance in Pseudomonas aeruginosa
A Dötsch, T Becker, C Pommerenke… - Antimicrobial agents …, 2009 - Am Soc Microbiol
The emergence of antimicrobial drug resistance is of enormous public concern due to the
increased risk of delayed treatment of infections, the increased length of hospital stays, the …
increased risk of delayed treatment of infections, the increased length of hospital stays, the …
Phylogroup-specific variation shapes the clustering of antimicrobial resistance genes and defence systems across regions of genome plasticity in Pseudomonas …
J Botelho, L Tüffers, J Fuss, F Buchholz, C Utpatel… - …, 2023 - thelancet.com
Background Pseudomonas aeruginosa is an opportunistic pathogen consisting of three
phylogroups (hereafter named A, B, and C). Here, we assessed phylogroup-specific …
phylogroups (hereafter named A, B, and C). Here, we assessed phylogroup-specific …
Genome-Scale Identification Method Applied to Find Cryptic Aminoglycoside Resistance Genes in Pseudomonas aeruginosa
JM Struble, RT Gill - PLoS One, 2009 - journals.plos.org
Background The ability of bacteria to rapidly evolve resistance to antibiotics is a critical
public health problem. Resistance leads to increased disease severity and death rates, as …
public health problem. Resistance leads to increased disease severity and death rates, as …
Genomic heterogeneity underlies multidrug resistance in Pseudomonas aeruginosa: A population-level analysis beyond susceptibility testing
LJ Rojas, M Yasmin, J Benjamino, SM Marshall… - PloS one, 2022 - journals.plos.org
Background Pseudomonas aeruginosa is a persistent and difficult-to-treat pathogen in many
patients, especially those with Cystic Fibrosis (CF). Herein, we describe a longitudinal …
patients, especially those with Cystic Fibrosis (CF). Herein, we describe a longitudinal …
Comparative genomics of a drug-resistant Pseudomonas aeruginosa panel and the challenges of antimicrobial resistance prediction from genomes
J Jeukens, I Kukavica-Ibrulj… - FEMS Microbiology …, 2017 - academic.oup.com
Antimicrobial resistance (AMR) is now recognized as a global threat to human health. The
accessibility of microbial whole-genome sequencing offers an invaluable opportunity for …
accessibility of microbial whole-genome sequencing offers an invaluable opportunity for …
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