Once the genome sequence of an organism is obtained, attention turns from identifying
genes to understanding their function, their organization and control of metabolic pathways …

Antimicrobial resistance (AMR) has become a global medical priority that needs urgent
resolution. Pseudomonas aeruginosa is a versatile, adaptable bacterial species with …

Patient-derived isolates of the opportunistic pathogen Pseudomonas aeruginosa are
frequently resistant to antibiotics due to the presence of sequence variants in resistance …

Although many mutations contributing to antibiotic resistance have been identified, the
relationship between the mutations and the related phenotypic changes responsible for the …

Pseudomonas aeruginosa is a relevant opportunistic pathogen particularly problematic due
to its low intrinsic susceptibility to antibiotics. Intrinsic resistance has been traditionally …

As a third-generation sequencing (TGS) method, single-molecule real-time (SMRT)
technology provides long read length, and it is well suited for resequencing projects and de …

Pseudomonas aeruginosa exploits intrinsic and acquired resistance mechanisms to resist
almost every antibiotic used in chemotherapy. Antimicrobial resistance in P. aeruginosa …

Pseudomonas aeruginosa, a main cause of human infection, can gain resistance to the
antibiotic aztreonam through a mutation in NalD, a transcriptional repressor of cellular efflux …

With the aim to identify potential new targets to restore antimicrobial susceptibility of
multidrug-resistant (MDR) Pseudomonas aeruginosa isolates, we generated a high-density …

ABSTRACT The CDC's Emerging Infections Program (EIP) conducted population-and
laboratory-based surveillance of US carbapenem-resistant Pseudomonas aeruginosa …