Understanding how evolution of antimicrobial resistance increases resistance to other drugs
is a challenge of profound importance. By combining experimental evolution and genome …

Collateral sensitivity is an evolutionary trade-off whereby acquisition of the adaptive
phenotype of resistance to an antibiotic leads to the nonadaptive increased susceptibility to …

Extensive use of next-generation sequencing (NGS) for pathogen profiling has the potential
to transform our understanding of how genomic plasticity contributes to phenotypic …

Pseudomonas aeruginosa causes acute and chronic infections in humans and these
infections are difficult to treat due to the bacteria's high-level of intrinsic and acquired …

With multi-drug and pan-drug-resistant bacteria becoming increasingly common in hospitals,
antibiotic resistance has threatened to return us to a pre-antibiotic era that would completely …

Microbial population polymorphisms are commonly observed in natural environments,
including long-term infected hosts. However, the underlying processes promoting and …

Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF)
contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its …

Current efforts to understand antibiotic resistance on the whole genome scale tend to focus
on known genes even as high throughput sequencing strategies uncover novel …

Detailed knowledge on how bacteria evade antibiotics and eventually develop resistance
could open avenues for novel therapeutics and diagnostics. It is thereby key to develop a …

Pseudomonas aeruginosa is an important opportunistic pathogen, especially in the context
of infections of cystic fibrosis (CF). In order to facilitate coordinated study of this pathogen, an …