Technological and methodological innovations are equipping researchers with
unprecedented capabilities for detecting and characterizing pathologic processes in the …

Abstract The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale, NIMH funded
initiative to understand how brain maturation mediates cognitive development and …

Background Psychiatric science remains descriptive, with a categorical nosology intended to
enhance interobserver reliability. Increased awareness of the mismatch between categorical …

Background The widespread use of Magnetic Resonance Imaging (MRI) in the study of child‐
and adult‐onset developmental psychopathologies has generated many investigations that …

Highlights•Resting-state fMRI biomarkers in psychiatry often lack disorder specificity.•
Transdiagnostic study designs allow direct assessment of biomarker specificity.•p-factor …

Mental disorders represent an increasing personal and financial burden and yet treatment
development has stagnated in recent decades. Current disease classifications do not reflect …

Human brain networks based on neuroimaging data have already proven useful in
characterizing both normal and abnormal brain structure and function. However, many brain …

Brain development has largely been studied through unimodal analysis of neuroimaging
data, providing independent results for structural and functional data. However, structure …

Many workflows and tools that aim to increase the reproducibility and replicability of
research findings have been suggested. In this review, we discuss the opportunities that …

The vast majority of mental illnesses can be conceptualized as developmental disorders of
neural interactions within the connectome, or developmental miswiring. The recent …