Astrocytes regulate extracellular glutamate and water homeostasis through the astrocyte-
specific membrane proteins glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) …

Astrocytes regulate extracellular glutamate homeostasis in the central nervous system
through the Na+-dependent glutamate transporters glutamate transporter-1 (GLT-1) and …

Recent evidence suggests that astrocytes may be a potential new target for the treatment of
epilepsy. The glial water channel aquaporin-4 (AQP4) is expressed in astrocytes, and along …

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Previous research
has demonstrated several trends in human tissue that, undoubtedly, contribute to the …

Epilepsies are common disorders of the central nervous system (CNS), affecting up to 2% of
the global population. Pharmaco‐resistance is a major clinical challenge affecting about …

Aims Glutamate neurotoxicity plays an important role in the pathogenesis of various
neurodegenerative disorders. Many studies have demonstrated that glutamate transporter‐1 …

It has been suggested that loss of the astrocytic water channel aquaporin-4 (AQP4) from
perivascular endfeet in sclerotic hippocampi contributes to increased seizure propensity in …

Recent studies have implicated glial cells in modulation of synaptic transmission, so it is
plausible that glial cells may have a functional role in the hyperexcitability characteristic of …

Abstract Aquaporin‐4 (AQP 4) and glutamate transporter‐1 (GLT‐1) represent the major
water and glutamate astrocyte buffering gateways in the brain. Utilizing perilesional …

The hippocampus of patients with mesial temporal lobe epilepsy is often hardened and
shrunken, a condition known as sclerosis. Magnetic resonance imaging reveals an increase …