The role of gap junction membrane channels in development

CW Lo - Journal of bioenergetics and biomembranes, 1996 - Springer
In most developmental systems, gap junction-mediated cell-cell communication (GJC) can
be detected from very early stages of embryogenesis. This usually results in the entire …

Expression of the gap junction proteins connexin31 and connexin43 correlates with communication compartments in extraembryonic tissues and in the gastrulating …

E Dahl, E Winterhager, B Reuß, O Traub… - Journal of Cell …, 1996 - journals.biologists.com
We have characterized the pattern of connexin expression in embryonic and extraembryonic
tissues during early mouse development. In the preimplantation blastocyst, at 3.5 days post …

Structure, sequence and expression of the mouse Cx43 gene encoding connexin 43

R Sullivan, C Ruangvoravat, D Joo, J Morgan… - Gene, 1993 - Elsevier
Gap junctions, membrane channels that mediate the diffusion of ions and small molecules
between cells, are hypothesized to play a role in development and growth regulation. The …

Spatial and temporal patterns of distribution of the gap junction protein connexin43 during mouse gastrulation and organogenesis

SB Yancey, S Biswal, JP Revel - Development, 1992 - journals.biologists.com
ABSTRACT Connexin43 (Cx43) is a member of the family of channel-forming proteins that
make up the gap junction and are believed to provide pathways for cell-cell exchange of …

Functional significance of gap junctional coupling in preimplantation development

FD Houghton, KJ Barr, G Walter… - Biology of …, 2002 - academic.oup.com
Gap junctional intercellular coupling allows cells to share low molecular weight metabolites
and second messengers, thus facilitating homeostatic and developmental processes. Gap …

Multiple members of the connexin gene family participate in preimplantation development of the mouse

TC Davies, KJ Barr, DH Jones, D Zhu… - Developmental …, 1996 - Wiley Online Library
The connexin gene family, of which there are at least 12 members in rodents, encodes the
protein subunits of intercellular membrane channels (gap junction channels). Because of the …

Genes, gene knockouts, and mutations in the analysis of gap junctions

CW Lo - Developmental genetics, 1999 - Wiley Online Library
Gap junctions are cell junctions found between most cells and tissues. They contain
membrane channels that mediate the cell‐to‐cell diffusion of ions, metabolites, and small …

Expression of connexin31 and connexin43 genes in early rat embryos

B Reuss, P Hellmann, O Traub… - Developmental …, 1997 - Wiley Online Library
Gap junctions have been reported to play a pivotal role in coordinating embryonic
development. Here we report the temporal and spatial pattern of connexin31 that has been …

Functional analysis of amino acid sequences in connexin43 involved in intercellular communication through gap junctions

DL Becker, WH Evans, CR Green… - Journal of cell …, 1995 - journals.biologists.com
Gap junctions allow direct communication between cells without recourse to the extracellular
space and have been widely implicated as important mediators of cell-cell signalling. They …

Connexin expression and functional analysis of gap junctional communication in mouse embryonic stem cells

P Wörsdörfer, S Maxeiner, C Markopoulos, G Kirfel… - Stem …, 2008 - academic.oup.com
Gap junctional intercellular communication (GJIC) has been suggested to be necessary for
cellular proliferation and differentiation. We wanted to investigate the function of GJIC in …