Regulation of gene expression by muscarinic acetylcholine receptors
H von der Kammer, C Demiralay… - Biochemical Society …, 2001 - portlandpress.com
In the brain, muscarinic acetylcholine receptors (mAChRs) are involved in higher cognitive
functions including synaptic plasticity and memory. In Alzheimer's disease (AD) patients the …
functions including synaptic plasticity and memory. In Alzheimer's disease (AD) patients the …
Selective Signaling via Unique Ml Muscarinic Agonistsa
A Fisher, E Heldman, D Gurwitz… - Annals of the New …, 1993 - Wiley Online Library
Rigid analogs of acetylcholine (ACh) were designed for selective actions at muscarinic
receptor (mAChR) subtypes and distinct second messenger systems. AF102B, AF150, and …
receptor (mAChR) subtypes and distinct second messenger systems. AF102B, AF150, and …
[图书][B] Impact of muscarinic agonists for successful therapy of Alzheimer's disease
A Fisher, R Brandeis, R Haring, N Bar-Ner… - 2002 - Springer
The Ml muscarinic agonists AF102B, AF150 (S) & AF267B—i) restored cognitive
impairments in several animal models for AD with an excellent safety margin; ii) elevated α …
impairments in several animal models for AD with an excellent safety margin; ii) elevated α …
Synthesis and Pharmacological Evaluation of Analogues of Benzyl Quinolone Carboxylic Acid (BQCA) Designed to Bind Irreversibly to an Allosteric Site of the M1 …
Activation of the M1 muscarinic acetylcholine receptor (mAChR) is a prospective treatment
for alleviating cognitive decline experienced in central nervous system (CNS) disorders …
for alleviating cognitive decline experienced in central nervous system (CNS) disorders …
Altered hippocampal muscarinic receptors in acetylcholinesterase‐deficient mice
LA Volpicelli‐Daley, EG Duysen… - Annals of …, 2003 - Wiley Online Library
A primary therapeutic strategy for Alzheimer's disease includes acetylcholinesterase (AChE)
inhibitors with the goal of enhancing cholinergic transmission. Stimulation of muscarinic …
inhibitors with the goal of enhancing cholinergic transmission. Stimulation of muscarinic …
The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque
JM Uslaner, D Eddins, V Puri, CE Cannon… - …, 2013 - Springer
Rationale The current standards of care for Alzheimer's disease, acetylcholinesterase
inhibitors, have limited efficacy due to a host of mechanism-related side effects arising from …
inhibitors, have limited efficacy due to a host of mechanism-related side effects arising from …
In vivo pharmacological comparison of TAK-071, a positive allosteric modulator of muscarinic M1 receptor, and xanomeline, an agonist of muscarinic M1/M4 receptor …
T Mandai, M Kasahara, E Kurimoto, M Tanaka… - Neuroscience, 2019 - Elsevier
Activation of the M 1 muscarinic acetylcholine receptor (M 1 R) may be an effective
therapeutic approach for Alzheimer's disease (AD), dementia with Lewy bodies, and …
therapeutic approach for Alzheimer's disease (AD), dementia with Lewy bodies, and …
Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice
W Zhang, AS Basile, J Gomeza… - Journal of …, 2002 - Soc Neuroscience
Forebrain muscarinic acetylcholine (ACh) receptors (mAChRs; M1-M5) are predicted to play
important roles in many fundamental central functions, including higher cognitive processes …
important roles in many fundamental central functions, including higher cognitive processes …
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning
DJ Sheffler, R Williams, TM Bridges, Z Xiang… - Molecular …, 2009 - ASPET
Previous studies suggest that selective antagonists of specific subtypes of muscarinic
acetylcholine receptors (mAChRs) may provide a novel approach for the treatment of certain …
acetylcholine receptors (mAChRs) may provide a novel approach for the treatment of certain …
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission
JK Shirey, Z Xiang, D Orton, AE Brady… - Nature chemical …, 2008 - nature.com
Muscarinic acetylcholine receptors (mAChRs) provide viable targets for the treatment of
multiple central nervous system disorders. We have used cheminformatics and medicinal …
multiple central nervous system disorders. We have used cheminformatics and medicinal …