[HTML][HTML] Quantitative phase imaging using digital holographic microscopy reliably assesses morphology and reflects elastic properties of fibrotic intestinal tissue

A Bokemeyer, PR Tepasse, L Quill, P Lenz, E Rijcken… - Scientific reports, 2019 - nature.com
Intestinal strictures are a frequent complication in patients with Crohn's Disease (CD) and
the presence of fibrosis within strictures impacts the therapeutic treatment approach. Here …

Multimodal quantitative phase imaging with digital holographic microscopy accurately assesses intestinal inflammation and epithelial wound healing

P Lenz, M Brückner, S Ketelhut, J Heidemann… - JoVE (Journal of …, 2016 - jove.com
The incidence of inflammatory bowel disease, ie, Crohn's disease and Ulcerative colitis, has
significantly increased over the last decade. The etiology of IBD remains unknown and …

Digital holographic microscopy quantifies the degree of inflammation in experimental colitis

P Lenz, D Bettenworth, P Krausewitz… - Integrative …, 2013 - academic.oup.com
Inflammatory bowel diseases including Crohn's disease and ulcerative colitis resemble a
large burden for patients due to the chronic course of disease. Therefore, there is an urgent …

[HTML][HTML] Quantitative phase imaging using digital holographic microscopy to assess the degree of intestinal inflammation in patients with ulcerative colitis

A Bokemeyer, J Buskermolen, S Ketelhut… - Journal of Clinical …, 2023 - mdpi.com
Ulcerative colitis (UC) is characterized by chronic inflammation of the colorectum.
Histological remission has emerged as a potential future treatment goal; however, the …

Quantitative phase microscopy for evaluation of intestinal inflammation and wound healing utilizing label-free biophysical markers

D Bettenworth, A Bokemeyer, C Poremba, NS Ding… - 2018 - digitum.um.es
Inflammatory bowel diseases (IBD) are inflammatory disorders of the gastrointestinal tract
characterized by a chronic relapsing disease course. As uncontrolled intestinal inflammation …

[HTML][HTML] Differentiation of fibrotic and inflammatory component of Crohn's disease-associated strictures

J Rimola, N Capozzi - Intestinal research, 2020 - ncbi.nlm.nih.gov
Patients with Crohn's disease (CD) commonly develop bowel strictures, which may contain
various degrees of inflammation and fibrosis. While predominantly inflammatory strictures …

[HTML][HTML] A new conversation between radiology and pathology-identifying microvascular architecture in stages of cirrhosis via diffraction enhanced imaging in vitro

D Hu, Y Chen, A Bihi, X Li, T Wang, B Wang, X Zhao - PLoS One, 2014 - journals.plos.org
Background/Aim Diffraction enhanced imaging (DEI) is a synchrotron radiation X-ray phase-
contrast imaging technique that can better reveal the microstructure of biological soft tissues …

[HTML][HTML] Determination of extracellular matrix collagen fibril architectures and pathological remodeling by polarization dependent second harmonic microscopy

D Rouède, E Schaub, JJ Bellanger, F Ezan… - Scientific reports, 2017 - nature.com
Polarization dependence second harmonic generation (P-SHG) microscopy is gaining
increase popularity for in situ quantification of fibrillar protein architectures. In this report, we …

Crohn's disease related strictures in cross‐sectional imaging: More than meets the eye?

J Sleiman, P Chirra, NS Gandhi… - United European …, 2022 - Wiley Online Library
Strictures in Crohn's disease (CD) are a hallmark of long‐standing intestinal damage,
brought about by inflammatory and non‐inflammatory pathways. Understanding the complex …

Contemporary Imaging Assessment of Strictures and Fibrosis in Crohn Disease, With Focus on Quantitative Biomarkers: From the AJR Special Series on Imaging of …

J Rimola, KJ Beek, I Ordás, KB Gecse… - American Journal of …, 2023 - Am Roentgen Ray Soc
Patients with Crohn disease commonly have bowel strictures develop, which exhibit varying
degrees of inflammation and fibrosis. Differentiation of the distinct inflammatory and fibrotic …