Aim Since foods with high hedonic value are often consumed in excess of energetic needs,
this study was designed to identify the mechanisms that may counter anorexigenic signalling …

Objective Leptin modulates food reward via central leptin receptor (LepRb) expressing
neurons. Food reward requires stimulation of midbrain dopamine neurons and is modulated …

Orexin-A and-B are neuropeptides that are implicated in the regulation of vigilance states
and energy homeostasis. Orexins are specifically produced by neurons located within the …

Timing activity to match resource availability is a widely conserved ability in nature.
Scheduled feeding of a limited amount of food induces increased activity prior to feeding …

Leptin reduces food intake in part by enhancing satiety responses to gastrointestinal signals
produced in response to food consumption. Glucagon-like peptide 1 (GLP-1), secreted by …

Leptin informs the brain about sufficiency of fuel stores. When insufficient, leptin levels fall,
triggering compensatory increases in appetite. Falling leptin is first sensed by hypothalamic …

Leptin acts centrally via leptin receptor (LepRb)-expressing neurons to regulate food intake,
energy expenditure, and other physiological functions. LepRb neurons are found throughout …

For survival, it is crucial for eating behaviours to be sequenced through two distinct seeking
and consummatory phases. Heterogeneous lateral hypothalamus (LH) neurons are known …

Leptin and ghrelin are known to be the main hormones involved in the control of food intake,
with opposite effects. Here we aimed to assess whether changes in leptin and ghrelin …

The hormones ghrelin and leptin act via the lateral hypothalamic area (LHA) to modify
energy balance, but the underlying neural mechanisms remain unclear. We investigated …