With rising rates of obesity, research continues to explore the contributions of homeostatic
and hedonic mechanisms related to eating behaviour. In this Review, we synthesize the …

Diet-induced obesity (DIO) resulting from consumption of a high fat diet (HFD) attenuates
normal neuronal responses to leptin and may contribute to the metabolic defense of an …

Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal
activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high …

Food deprivation stimulates foraging and hoarding and to a much lesser extent, food intake
in Siberian hamsters. Leptin, the anorexigenic hormone secreted primarily from adipocytes …

Glucose inhibits∼ 60% of lateral hypothalamic (LH) orexin neurons. Fasting increases the
activation of LH orexin glucose-inhibited (GI) neurons in low glucose. Increases in …

The hormones leptin and ghrelin act in apposition to one another in the regulation of body
weight homeostasis. Interestingly, both leptin receptor expression and ghrelin receptor …

Hypocretins/orexins are recently characterized peptides that are synthesized in neurones of
the lateral hypohalamus and stimulate food intake in rats. To clarify whether leptin may …

It has been established that leptin exerts a negative control on food intake, allowing one to
maintain stable caloric intake over time. The aim of the present study was to investigate …

Palatable taste can stimulate appetite in the absence of hunger, and individual differences in
hedonic eating may be critical to overeating. Women are more prone to obesity and binge …

Brief, high-concentration (phasic) spikes in nucleus accumbens dopamine critically
participate in aspects of food reward. Although physiological state (eg, hunger, satiety) and …