[HTML][HTML] Stimulation of appetite by ghrelin is regulated by leptin restraint: peripheral and central sites of action

SP Kalra, N Ueno, PS Kalra - The Journal of nutrition, 2005 - Elsevier
ABSTRACT A reciprocal rhythmic pattern of 2 afferent hormonal signals, anorexigenic leptin
and orexigenic ghrelin, imparts rhythmicity to the neuropeptide Y (NPY) system, the final …

Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity

LAW Verhagen, E Egecioglu, MCM Luijendijk… - European …, 2011 - Elsevier
Using the rodent activity-based anorexia (ABA) model that mimics clinical features of
anorexia nervosa that include food restriction-induced hyperlocomotion, we found that …

Overeating of palatable food is associated with blunted leptin and ghrelin responses

A Lindqvist, CD de la Cour, A Stegmark, R Håkanson… - Regulatory peptides, 2005 - Elsevier
Palatable food is rich in fat and/or sucrose. In this study we examined the long-term effects of
such diets on food intake, body weight, adiposity and circulating levels of the satiety peptide …

Leptin-induced downregulation of the rat hippocampal somatostatinergic system may potentiate its anorexigenic effects

A Perianes-Cachero, E Burgos-Ramos… - Neurochemistry …, 2012 - Elsevier
The learning and memory mechanisms in the hippocampus translate hormonal signals of
energy balance into behavioral outcomes involved in the regulation of food intake. As leptin …

Leptin deficiency induced by fasting impairs the satiety response to cholecystokinin

JE McMinn, DK Sindelar, PJ Havel… - Endocrinology, 2000 - academic.oup.com
Leptin administration potentiates the satiety response to signals such as cholecystokinin
(CCK), that are released from the gut during a meal. To investigate the physiological …

Effect of food availability and leptin on the physiology and hypothalamic gene expression of the golden spiny mouse: a desert rodent that does not hoard food

R Gutman, R Hacmon-Keren… - American Journal …, 2008 - journals.physiology.org
Food availability and quality in desert habitats are spatially and temporally unpredictable,
and animals face periods of food shortage. The golden spiny mouse (Acomys russatus) is an …

Ghrelin and orexin interact to increase meal size through a descending hippocampus to hindbrain signaling pathway

AN Suarez, CM Liu, AM Cortella, EE Noble… - Biological …, 2020 - Elsevier
Background Memory and cognitive processes influence the amount of food consumed
during a meal, yet the neurobiological mechanisms mediating these effects are poorly …

Maintenance on a high-fat diet impairs the anorexic response to glucagon-like-peptide-1 receptor activation

DL Williams, N Hyvarinen, N Lilly, K Kay, A Dossat… - Physiology & …, 2011 - Elsevier
Previous data suggests that the adiposity signal leptin reduces food intake in part by
enhancing sensitivity to short-term signals that promote meal termination, including …

Presynaptic regulation of leptin in a defined lateral hypothalamus–ventral tegmental area neurocircuitry depends on energy state

JJ Liu, NT Bello, ZP Pang - Journal of Neuroscience, 2017 - Soc Neuroscience
Synaptic transmission controls brain activity and behaviors, including food intake. Leptin, an
adipocyte-derived hormone, acts on neurons located in the lateral hypothalamic area (LHA) …

The need to feed: homeostatic and hedonic control of eating

CB Saper, TC Chou, JK Elmquist - Neuron, 2002 - cell.com
Feeding provides substrate for energy metabolism, which is vital to the survival of every
living animal and therefore is subject to intense regulation by brain homeostatic and hedonic …