Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the
small intestine, has been validated as a key therapeutic target to ameliorate the intestinal …

Abstract Human carboxylesterase 2 (CES2A), one of the most abundant hydrolases
distributed in human small intestine and colon, play key roles in the hydrolysis of a wide …

Human carboxylesterases (hCEs) are key enzymes from the serine hydrolase superfamily.
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …

Abstract Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes,
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …

Abstract Human Carboxylesterase 2A (hCES2A), one of the most important serine
hydrolases, plays crucial roles in the hydrolysis and the metabolic activation of a wide range …

Human carboxylesterase 2 (hCES2A) is a key target to ameliorate the intestinal toxicity
triggered by irinotecan that causes severe diarrhea in 50%–80% of patients receiving this …

Abstract Human carboxylesterase 2A (hCES2A), the most abundant carboxylesterase in the
human gut, plays a crucial role in the metabolic clearance and activation of various ester …

Fructus psoraleae (FP) is the dried ripe seeds of Psoralea corylifolia L.(Fabaceae) widely
used in Asia, and has been reported to exert important biochemical and pharmacological …

Abstract Human carboxylesterase 1 (hCE1) is a key enzyme responsible for the hydrolysis of
a wide range of endogenous and xenobiotic esters, but the highly selective inhibitors …

Abstract Human carboxylesterase 2 (hCES2A), one of the most important serine hydrolases
distributed in the small intestine and colon, plays a crucial role in the hydrolysis of various …