The 5-HT2A serotonin receptor in executive function: Implications for neuropsychiatric and neurodegenerative diseases

S Aznar, MES Hervig - Neuroscience & Biobehavioral Reviews, 2016 - Elsevier
Executive function entails the interplay of a group of cognitive processes enabling the
individual to anticipate consequences, attain self-control, and undertake appropriate goal …

Serotonin and brain function: a tale of two receptors

RL Carhart-Harris, DJ Nutt - Journal of psychopharmacology, 2017 - journals.sagepub.com
Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression

P Cowen, AC Sherwood - Journal of psychopharmacology, 2013 - journals.sagepub.com
Background: Symptoms of cognitive impairment such as poor concentration, memory loss
and difficulty with decision making are prevalent in patients with depression, but currently …

5-HT2A: its role in frontally mediated executive function and related psychopathology

DJ Stein, S Hemmings, H Moolman-Smook… - CNS …, 2007 - cambridge.org
Serotonin (5-HT) 2A receptors are widely distributed, with high levels in the frontal cortex,
where postsynaptic activation may increase activity in pyramidal glutamatergic neurons and …

Molecular imaging of the 5-HT1A receptor in relation to human cognition

J Borg - Behavioural brain research, 2008 - Elsevier
Animal studies and pharmacological studies in man have suggested that the serotonin 5-
HT1A receptor may serve as a biomarker for cognitive functioning and a target for treatment …

[HTML][HTML] The serotonin-6 receptor as a novel therapeutic target

HM Yun, H Rhim - Experimental neurobiology, 2011 - ncbi.nlm.nih.gov
Abstract Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that is found
in both the central and peripheral nervous systems. 5-HT mediates its diverse physiological …

5-HT1A receptor-regulated signal transduction pathways in brain

AM Polter, X Li - Cellular signalling, 2010 - Elsevier
Serotonin is an influential monoamine neurotransmitter that signals through a number of
receptors to modulate brain function. Among different serotonin receptors, the serotonin 1A …

[HTML][HTML] 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease

N Upton, TT Chuang, AJ Hunter, DJ Virley - Neurotherapeutics, 2008 - Elsevier
Alzheimer's disease (AD) is a devastating neurological condition characterized by a
progressive decline in cognitive performance accompanied by behavioral and psychological …

Cognitive dysfunction in neuropsychiatric disorders: selected serotonin receptor subtypes as therapeutic targets

AV Terry Jr, JJ Buccafusco, C Wilson - Behavioural Brain Research, 2008 - Elsevier
The indolamine, serotonin (5-hydroxytryptamine-5-HT) was identified and initially
characterized around the middle of the twentieth century and it is now known to participate in …

Search for correlations between serotonin 5-HT1A receptor expression and cognitive functions—a strategy in translational psychopharmacology

J Borg, B Andrée, J Lundberg, C Halldin, L Farde - Psychopharmacology, 2006 - Springer
Rationale Animal studies and studies of human aging have suggested that the serotonin 5-
HT 1A receptor may serve as a biomarker for cognitive functioning and a target for …