[HTML][HTML] IL-22 down-regulates Cx43 expression and decreases gap junctional intercellular communication by activating the JNK pathway in psoriasis
J Liang, P Chen, C Li, D Li, J Wang, R Xue… - Journal of Investigative …, 2019 - Elsevier
The roles of IL-22 in the pathomechanisms of psoriasis have been well demonstrated. Gap
junctional intercellular communication (GJIC) is widely known for its involvement in multiple …
junctional intercellular communication (GJIC) is widely known for its involvement in multiple …
[HTML][HTML] The pro-inflammatory cytokine IL-22 up-regulates keratin 17 expression in keratinocytes via STAT3 and ERK1/2
W Zhang, E Dang, X Shi, L Jin, Z Feng, L Hu, Y Wu… - PloS one, 2012 - journals.plos.org
Background To investigate the regulation of K17 expression by the pro-inflammatory
cytokine IL-22 in keratinocytes and its important role in our previously hypothesized “K17/T …
cytokine IL-22 in keratinocytes and its important role in our previously hypothesized “K17/T …
[HTML][HTML] Biological effects of IL-26 on T cell–mediated skin inflammation, including psoriasis
Psoriasis is a chronic inflammatory skin disease characterized mainly by epidermal
hyperplasia, scaling, and erythema; T helper 17 cells have a role in its pathogenesis …
hyperplasia, scaling, and erythema; T helper 17 cells have a role in its pathogenesis …
[HTML][HTML] Induction of interleukin-22 (IL-22) production in CD4+ T cells by IL-17A secreted from CpG-stimulated keratinocytes
ZJ Li, DK Choi, KC Sohn, SK Lim, M Im… - Annals of …, 2016 - synapse.koreamed.org
Background Interleukin-17A (IL-17A) is mainly secreted from Th17 cells that are activated by
various stimuli including CpG oligodeoxynucleotide, a Toll-like receptor 9 (TLR9) ligand …
various stimuli including CpG oligodeoxynucleotide, a Toll-like receptor 9 (TLR9) ligand …
IL‐33 is secreted by psoriatic keratinocytes and induces pro‐inflammatory cytokines via keratinocyte and mast cell activation
A Balato, S Lembo, M Mattii… - Experimental …, 2012 - Wiley Online Library
IL‐33 is a novel pro‐inflammatory cytokine and ligand for the orphan receptor ST 2.
Although originally defined as an inducer of T h2‐mediated responses, IL‐33 was recently …
Although originally defined as an inducer of T h2‐mediated responses, IL‐33 was recently …
[HTML][HTML] Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax
B Wang, D Han, F Li, W Hou, L Wang, L Meng, K Mou… - Apoptosis, 2020 - Springer
IL-22 is known to mediate inflammation in psoriasis, while IL-22 binding protein (IL-22BP)
binds IL-22 to suppress IL-22 signaling. However, the function of IL-22 in regulating …
binds IL-22 to suppress IL-22 signaling. However, the function of IL-22 in regulating …
Interleukin (IL)-18, cooperatively with IL-23, induces prominent inflammation and enhances psoriasis-like epidermal hyperplasia
N Shimoura, H Nagai, S Fujiwara, H Jimbo… - Archives of …, 2017 - Springer
Abstract The interleukin (IL)-23/IL-17 axis is strongly implicated in the pathogenesis of
psoriasis. Previous studies showed that IL-18 was elevated in early active and progressive …
psoriasis. Previous studies showed that IL-18 was elevated in early active and progressive …
Interleukin‐33 alleviates psoriatic inflammation by suppressing the T helper type 17 immune response
Z Chen, Y Hu, Y Gong, X Zhang, L Cui, R Chen… - …, 2020 - Wiley Online Library
Psoriasis is a chronic inflammatory skin disease with unclear pathogenesis. Interleukin‐33
(IL‐33) is highly expressed in patients with psoriasis, but its role in psoriasis is unknown …
(IL‐33) is highly expressed in patients with psoriasis, but its role in psoriasis is unknown …
[HTML][HTML] An autocrine circuit of IL-33 in keratinocytes is involved in the progression of psoriasis
F Zeng, H Chen, L Chen, J Mao, S Cai, Y Xiao… - Journal of Investigative …, 2021 - Elsevier
IL-33 is constitutively expressed in the skin. Psoriasis is a common skin inflammatory
disease. The roles of IL-33 in psoriasis have not been well-elucidated. We identified that …
disease. The roles of IL-33 in psoriasis have not been well-elucidated. We identified that …
[引用][C] Calcipotriol modulates IL-22 receptor expression and keratinocyte proliferation in IL-22-induced epidermal hyperplasia
To explain how calcipotriol decreases the responsiveness of KCs to IL-22, we hypothesized
that calcipotriol may decrease the expression level of IL-22 receptor (IL-22R) on KCs. To …
that calcipotriol may decrease the expression level of IL-22 receptor (IL-22R) on KCs. To …