The classical model of cytosine DNA methylation (the presence of 5-methylcytosine, 5mC)
regulation depicts this covalent modification as a stable repressive regulator of promoter …

DNA methylation dynamics influence brain function and are altered in neurological
disorders. 5-hydroxymethylcytosine (5-hmC), a DNA base that is derived from 5 …

Background DNA methylation is an epigenetic mechanism essential for gene regulation and
vital for mammalian development. 5-hydroxymethylcytosine (5hmC) is the first oxidative …

Abstract DNA 5-hydroxymethylcytosine (5hmC) modification is known to be associated with
gene transcription and frequently used as a mark to investigate dynamic DNA methylation …

Cytosine DNA methylation (5mC) is a widespread base modification in eukaryotic genomes
with critical roles in transcriptional regulation. In recent years, our understanding of 5mC has …

DNA methylation 5-methylcytosine (5mC) predicts a compacting chromatin inaccessible to
transcription. The discovery of 5-hydroxymethylcytosine (5hmC), which is derived from 5mC …

Abstract In mammals, DNA 5-hydroxymethylcytosine (5hmC) is involved in methylation
reprogramming during early embryonic development. Yet, to what extent 5hmC participates …

DNA methylation at the fifth position of cytosines (5mC) represents a major epigenetic
modification in mammals. The recent discovery of 5-hydroxymethylcytosine (5hmC) …

In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance
was not intuitive for several decades. After this initial lag, the ubiquitous presence of this …

The recent advent of high-throughput sequencing technologies coupled with RNA
modifications detection methods has allowed the detection of RNA modifications at single …