Understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers

HX Lim, TS Kim, CL Poh - International journal of molecular sciences, 2020 - mdpi.com
There has been a great interest in myeloid-derived suppressor cells (MDSCs) due to their
biological functions in tumor-mediated immune escape by suppressing antitumor immune …

Landscape of myeloid-derived suppressor cell in tumor immunotherapy

Z Hao, R Li, Y Wang, S Li, Z Hong, Z Han - Biomarker Research, 2021 - Springer
Myeloid-derived suppressor cells (MDSC) are a group of immature cells that produced by
emergency myelopoiesis. Emerging evidences have identified the vital role of MDSC in …

Novel characterization of myeloid-derived suppressor cells in tumor microenvironment

Y Li, H He, R Jihu, J Zhou, R Zeng… - Frontiers in Cell and …, 2021 - frontiersin.org
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of cells generated in
various pathologic conditions, which have been known to be key components of the tumor …

Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer

K Li, H Shi, B Zhang, X Ou, Q Ma, Y Chen… - Signal transduction and …, 2021 - nature.com
Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …

Expansion and functions of myeloid-derived suppressor cells in the tumor microenvironment

P Qu, L Wang, PC Lin - Cancer letters, 2016 - Elsevier
Myeloid derived suppressor cells (MDSCs) are a group of immature myeloid cells
accumulated in most cancer patients and mouse tumor models. MDSCs suppress host …

Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion

J Lu, Y Luo, D Rao, T Wang, Z Lei, X Chen… - … Hematology & Oncology, 2024 - Springer
Paradoxically, tumor development and progression can be inhibited and promoted by the
immune system. After three stages of immune editing, namely, elimination, homeostasis and …

Negative regulation of myeloid-derived suppressor cells in cancer

P Qu, KC Boelte, PC Lin - Immunological investigations, 2012 - Taylor & Francis
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature
myeloid cells with suppressive function on immune response. In this review, we discuss …

The recent progress of myeloid‐derived suppressor cell and its targeted therapies in cancers

R Ren, C Xiong, R Ma, Y Wang, T Yue, J Yu… - MedComm, 2023 - Wiley Online Library
Myeloid‐derived suppressor cells (MDSCs) are an immature group of myeloid‐derived cells
generated from myeloid cell precursors in the bone marrow. MDSCs appear almost …

The new era of cancer immunotherapy: targeting myeloid-derived suppressor cells to overcome immune evasion

P De Cicco, G Ercolano, A Ianaro - Frontiers in immunology, 2020 - frontiersin.org
Suppression of antitumor immune responses is one of the main mechanisms by which tumor
cells escape from destruction by the immune system. Myeloid-derived suppressor cells …

Roles of myeloid-derived suppressor cells in cancer metastasis: immunosuppression and beyond

A Pastaki Khoshbin, M Eskian… - Archivum Immunologiae …, 2019 - Springer
Metastasis is the direst face of cancer, and it is not a feature solely dependent on cancer
cells; however, a complex interaction between cancer cells and host causes this process …