Rationale Drug addiction is a multifactorial disorder resulting from an interaction between
genetic and environmental factors, and negative and positive environmental conditions may …

Rationale The place conditioning procedure is increasingly used to study relapse in drug
seeking in mice. However, the retention course of drug-induced place preference has not …

Reinstatement of drug-seeking behavior in animals is relevant to drug relapse in humans. In
the present study, we employed the conditioned place preference (CPP) paradigm to …

Rationale Relapse to drug use after periods of forced or self-imposed abstinence is a central
problem in the treatment of addiction; therefore, identification of factors modulating the risk to …

Rats allowed extended access to cocaine self-administration develop a number of
symptoms of addiction, such as greater susceptibility to drug-induced relapse. Using the …

To explore sex differences in reinstatement of conditioned place preference, we subjected
intact male and female Long Evans rats to an extended conditioned place preference (CPP) …

Background: Substance use disorder emerges in a small proportion of drug users and has
the characteristics of a chronic relapsing pathology. Aims: Our study aimed to demonstrate …

The rewarding effect of cocaine as reflected by the development of conditioned place
preference was examined in C57BL/6J and 129/J mice. Cocaine was administered in a …

The development and maintenance of cocaine addiction depend heavily on learned reward-
environment associations that can induce drug-seeking behavior and relapse …

Rationale: In previous comparisons with C57BL/6J mice, DBA/2J mice have been
characterized as” hyporesponsive” to cocaine's rewarding effect in the conditioned place …