Abstract Objectives: Endothelin-1 (ET-1) is a potent vasoconstrictor that is expressed in
endothelial cells and in many other cells and tissues. Increased plasma levels of the peptide …

Endothelin-1 (ET-1) is a peptide hormone with potent vasoconstrictor properties that is
synthesized and secreted predominantly by vascular endothelial cells. Its production is …

Endothelin-1 (ET-1) is a peptide hormone with potent vasoconstrictor properties which is
synthesized and secreted predominantly by vascular endothelial cells. Its production is …

The current study tested the hypothesis that exposure to hypoxia enhances endothelin-1 (ET-
1) gene expression and elevates circulating ET-1 levels in the rat. Rats were exposed to …

Abstract Endothelin-1 (Et-1) is a vasoconstrictor peptide that plays an important role in the
pathophysiology of hypertension, myocardial ischemia, and other diseases. We examined …

Abstract Endothelin-1 (ET-1), a peptide product of endothelial cells, is mitogenic for
fibroblasts and smooth muscle cells. In this study we examined the effect of hypoxia on ET-1 …

Biochemical and molecular biological evidence indicates that endothelin (ET)-1 and its
receptors are selectively upregulated in the lung during exposure to hypoxia, while …

We and other groups have reported that endothelin (ET)-1 expression in the heart is altered
in the setting of heart diseases. We have also reported that myocardial ET-1 is involved in …

Endothelin (ET)-1 is a potent vasoconstrictor elicited from endothelial cells in response to a
variety of stimuli and an important mediator for a variety of vascular diseases including …

Our previous studies demonstrated that exposure to hypoxia increases pulmonary artery
pressure and plasma endothelin-1 (ET-1) levels and selectively enhances ET-1 gene …