Hypertension is associated with increased activity of the kallikrein–kinin system. Kinin B1
receptor (B1R) activation leads to vasoconstriction and inflammation. Despite evidence …

Kinins are a family of oligopeptides of the kallikrein-kinin system that act as potent
vasoactive hormones and inflammatory mediators. The bioactive kinins mainly consist of …

Hypertension is associated with increased expression of kinin B1 receptors (B1R) and
increased levels of pro-inflammatory cytokines within the neurons. We previously reported …

The present study was performed to examine the role of endogenous bradykinin (BK) in the
development of angiotensin II (Ang II)–induced hypertension in mice. BK B2 receptor …

Despite many readily available therapies, hypertensive kidney disease remains the second
most prevalent cause of end-stage renal disease after diabetes, and continues to burden …

Bradykinin normally exerts its vasodilatory effect via the B2 receptor (B2R), but in this
receptor's absence, the B1 receptor becomes expressed and activated. To explore the …

The B1 type receptor of bradykinin (Bk B1R) is believed to be physiologically inert but highly
inducible by inflammatory mediators and tissue damage. To explore the potential …

To clarify the role of the kallikrein-kinin system in cardiovascular homeostasis, the systemic
and regional hemodynamics of kinin B2 receptor–deficient (B2−/−) and tissue kallikrein …

We demonstrated that rat kinin B 1 receptors displayed a ligand-independent constitutive
activity, assessed through inositol phosphate production in transiently or stably transfected …

The kallikrein-kinin system plays important roles in blood pressure regulation, metabolism of
electrolytes and organ protection. Although the bradykinin B2 receptor (B2R) has been …