Few genetic risk factors have been demonstrated to be specifically associated with
aggressive prostate cancer (PrCa). Here, we report a case‐case study of PrCa comparing …

Simple Summary Identifying which men at the time of prostate cancer diagnosis have, or will
progress to, an aggressive fatal disease will allow clinicians to assist men in making better …

Objective Prostate cancer is the second most frequent cancer in men worldwide and kills
over 250,000 men worldwide every year. Prostate cancer is a heterogeneous disease at the …

Improvements in DNA sequencing technology and discoveries made by large scale genome-
wide association studies have led to enormous insight into the role of genetic variation in …

Simple Summary The potential importance of germline genetic variation for identifying men
at increased risk of prostate cancer has become increasingly recognised in recent years. We …

The inherited link of prostate cancer predisposition has been supported using data from
early epidemiological studies, as well as from familial and twin studies. Early linkage …

Goh CL, Schumacher FR, Easton D, Muir K, Henderson B, Kote‐Jarai Z, Eeles RA (The
Institute of Cancer Research, Sutton, Surrey, UK; Keck School of Medicine, University of …

Background Association studies have become a common and popular method to identify
genetic variants predisposing to complex diseases. Despite considerable efforts and initial …

Dramatic progress has been made in the area of germline genetics of prostate cancer (PCa)
in the past decade. Both common and rare genetic variants with effects on risk ranging from …

Simple Summary In this study, we identified germline mutations that contribute to prostate
cancer development in men who have multiple relatives with prostate cancer (and other …