Prostate cancer (PC) has the highest degree of genetic transmission of any form of
malignancy. In some families, the hereditary pattern is so strong as to mimic an autosomal …

Background Family history of prostate cancer (PCa) is a well-known risk factor, and both
common and rare genetic variants are associated with the disease. Objective To detect new …

To identify rare variants associated with prostate cancer susceptibility and better
characterize the mechanisms and cumulative disease risk associated with common risk …

Although prostate cancer is known to have a strong genetic basis and is influenced by both
common and rare variants, the ability to investigate the combined effect of such genetic risk …

Prostate cancer is the second most common malignancy affecting men worldwide, and the
commonest affecting men of African descent. Significant diagnostic and therapeutic …

Prostate cancer is the most common cancer in men and the second highest cause of cancer-
related mortality in the UK A genetic component in predisposition to prostate cancer has …

Prostate cancer is the most frequent cancer among men in most developed countries, yet
little is known about its causes. Older age, African ancestry and a positive family history of …

BACKGROUND Prostate cancer is a heterogeneous disease, both genetically and
phenotypically. Linkage studies attempting to map genes for hereditary prostate cancer …

Abstract Background Prostate cancer (PrCa) is a substantial cause of mortality among men
globally. Rare germline mutations in BRCA2 have been validated robustly as increasing risk …

Understanding the impact of multiple genetic variants and their interactions on the disease
penetrance of familial multiple prostate cancer is very relevant to the overall understanding …