Rationale: Cigarette smoke exposure is a risk factor for many lung diseases, and histologic
studies suggest that tobacco-related vasoconstriction and vessel loss plays a role in the …

Background Exposure to cigarette smoke has been shown to lead to vascular remodelling.
Computed tomography (CT) imaging measures of vascular pruning have been associated …

Rationale: Angiographic investigation suggests that pulmonary vascular remodeling in
smokers is characterized by distal pruning of the blood vessels. Objectives: Using volumetric …

Radiographic abnormalities of the pulmonary vessels, such as vascular pruning, are
common in advanced airways disease, but it is unknown if pulmonary vascular volumes are …

Rationale: Cigarette smoking is a risk factor for diffuse parenchymal lung disease. Risk
factors for subclinical parenchymal lung disease have not been described. Objectives: To …

Background This study sought to determine pulmonary vascular volumes (PVVs) on low-
dose computed tomography (LDCT) in a healthy male Chinese population and analyze the …

Pulmonary vascular disease is a common complication of chronic obstructive pulmonary
disease (COPD), and an important risk factor for COPD exacerbations and death. We …

Objective Prior work has described the relationship between pulmonary vascular pruning on
computed tomography (CT) scans and metrics of right-sided heart dysfunction in smokers. In …

Pulmonary hypertension is characterized histologically by intimal and medial thickening in
the small pulmonary arteries, eventually resulting in vascular “pruning.” Computed …

Background Evaluation of impaired left ventricular (LV) filling has focused on intrinsic
causes of LV dysfunction; however, pulmonary vascular changes may contribute to reduced …