FOXO proteins are a conserved family of transcription factors that regulate metabolism,
stress responses, and aging. The misregulation of FOXO proteins is associated with cancer …

The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

In Caenorhabditis elegans, there is a single FOXO transcription factor homolog, encoded by
the gene, daf-16. As a central regulator for multiple signaling pathways, DAF-16 integrates …

The insulin/IGF-1 signaling pathway is evolutionarily conserved and its function is mediated
largely by FOXO transcription factors. Reduced insulin/IGF-1 signaling leads to translocation …

The nematode Caenorhabditis elegans possesses a unique (with various isoforms) FOXO
transcription factor DAF-16, which is notorious for its role in aging and its regulation by the …

Background Forkhead transcription factors belonging to the FOXO subfamily are negatively
regulated by protein kinase B (PKB) in response to signaling by insulin and insulin-like …

Background Components of theinsulin signaling pathway are important regulators of growth.
TheFOXO (f orkhead b ox, sub-group" O") transcriptionfactors regulate cellular processes …

Forkhead box O (FoxO) transcription factors FoxO1, FoxO3a, FoxO4 and FoxO6, the
mammalian orthologs of Caenorhabditis elegans DAF-16, are emerging as an important …

Antagonism between growth‐promoting and stress‐responsive signaling influences tissue
homeostasis and longevity in metazoans. The transcription factor FoxO is central to this …

There is increasing evidence that Forkhead box 'Other'(FoxO) proteins, a subgroup of the
Forkhead transcription factor family, have an important role in mediating the effects of insulin …