Methods In the ORATORIO phase III clinical study 732 PPMS patients were randomized in a
2: 1 ratio to treatment with ocrelizumab 600mg or placebo. Expanded Disability Status Scale …

IntroductionTo facilitate communication of clinical study results among patients, clinicians,
and payers, this post-hoc analysis examined the association between achieving the Health …

Background The EQ-5D, a generic health status questionnaire that is widely used in health
economic evaluation, was recently expanded to the EQ-5D-5L to address criticisms of …

Background To determine whether healthcare resources are allocated fairly, it is helpful to
have information on the quality of life (QoL) of patients with Unexplained Physical Symptoms …

Worldwide policy makers are challenged to account for rising healthcare costs and
increased healthcare demand. Also, in the Netherlands there is a growing concern how to …

Objectives. To assess the interchangeability of preference-based health-related quality of
life tools and compare the potential gains in quality-adjusted life years (QALYs) in patients …

Purpose: To facilitate meaningful interpretation of the values reported for Work Productivity
and Activity Impairment (WPAI) and the 5-level EuroQol-5 Dimensions (EQ-5D-5L), we …

Objectives Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease
that effects mainly the optic nerves and spinal cord and if untreated can cause blindness …

Objectives A common criticism of utilities derived from vignettes is that there is little evidence
to support the validity of the vignettes as descriptions of the health state. It is generally …

Objective. Treatment in general is mostly directly aimed at disease activity, and measures
such as the DAS28 might therefore present important additional information. Our aim was to …