Obesity is increasing in prevalence across all sectors of society, and with it a constellation of
associated ailments including hypertension, type 2 diabetes, and eating disorders. The …

The rise in the global prevalence of human obesity has emphasized the need for a greater
understanding of the physiological mechanisms that underlie energy homeostasis …

There is overwhelming evidence that the brain melanocortin system is a key regulator of
energy balance, and dysregulations in the brain melanocortin system can lead to obesity …

▪ Abstract Animals have developed highly adaptive and redundant mechanisms to maintain
energy balance by matching caloric intake to caloric expenditure. Recent evidence has …

Studies have suggested that manipulations of the central melanocortin circuitry by
pharmacological agents produce robust effects on the regulation of body weight and …

The prevalence of obesity and the associated comorbidities highlight the importance of
understanding the regulation of energy homeostasis. The central melanocortin system plays …

The burden of disability, premature death, escalating health care costs and lost economic
productivity due to obesity and its associated complications including hypertension, stroke …

Obesity has become one of the most significant public health problems facing the world
today. However, the pathogenesis of obesity is multifactorial and involves the interaction of …

Accumulating evidence indicates that the central melanocortin (MC) system plays a key role
in the regulation of food intake and energy balance. This evidence includes findings that …

The central melanocortin system is comprised of discrete populations of neurons and circuits
that play a key role in maintaining energy balance. This system can sense levels of …