Understanding the neurobiological processes that incite drug craving and drive relapse has
the potential to help target efforts to treat addiction. The NAc serves as a critical substrate for …

Plasticity of glutamatergic synapses is a fundamental mechanism through which experience
changes neural function to impact future behavior. In animal models of addiction …

Despite evidence that morphine-related pathologies reflect adaptations in NAc glutamate
signaling, substantial gaps in basic information remain. The current study examines the …

The functional integrity of the nucleus accumbens (NAC) core and shell is necessary for
contextual cocaine‐seeking behavior in the reinstatement animal model of drug relapse; …

This study examined the role of group1 metabotropic glutamate receptor mGluR5 and
associated postsynaptic scaffolding protein Homer1b/c in behavioral plasticity after three …

Withdrawal from repeated cocaine is associated with increased synaptic and extrasynaptic
AMPA receptor (AMPAR) expression in nucleus accumbens (NAc) neurons and enhanced …

Cue-induced cocaine craving progressively intensifies (incubates) after withdrawal from
cocaine self-administration in rats and humans. In rats, the expression of incubation …

Addiction is a behavioral disease, of which core components can be modeled in rodents.
Much evidence implicates drug-evoked synaptic plasticity in cocaine-evoked locomotor …

Exposure to cocaine generates silent synapses in the nucleus accumbens (NA c), whose
eventual unsilencing/maturation by recruitment of calcium‐permeable AMPA‐type glutamate …

Accumulating evidence suggests that metabotropic glutamate receptors (mGluRs) are
involved in both cocaine reinforcement and the reinstatement of cocaine-seeking behavior …