Experience-dependent synaptic plasticity is an important component of both learning and
motivational disturbances found in addicted individuals. Here, we investigated the role of …

Neuroadaptation in the nucleus accumbens (NAc), a central component of the mesolimbic
dopamine (DA) system, has been implicated in the development of cocaine-induced …

Rationale The functional integrity of the dorsal hippocampus (DH) is necessary for drug
context-induced reinstatement of cocaine seeking. However, the neuropharmacological …

Repeated exposure to psychostimulant drugs such as cocaine or amphetamine can promote
drug-seeking and-taking behavior. In rodent addiction models, persistent changes in …

Background The development and persistence of addiction is mediated in part by drug-
induced alterations in nucleus accumbens (NAc) function. AMPA-type glutamate receptors …

Cue-induced cocaine craving is a major cause of relapse in abstinent addicts. In rats, cue-
induced craving progressively intensifies (incubates) during withdrawal from extended …

Cue-induced cocaine craving in rodents intensifies or “incubates” during the first months of
withdrawal from long access cocaine self-administration. This incubation phenomenon is …

Trafficking and stabilization of AMPA receptors at synapses in response to cocaine exposure
is thought to be critical for expression of cocaine addiction and relapse. Glutamate receptor …

Glutamate signaling in the nucleus accumbens influences reinstatement of previously
extinguished cocaine-seeking behavior in rats. Whether or not region specific glutamate …

Background Cue-induced cocaine craving progressively intensifies (incubates) during
abstinence from cocaine self-administration. Expression of incubated cocaine craving …