AMPA receptor and metabotropic glutamate receptor 1 adaptations in the nucleus accumbens core during incubation of methamphetamine craving
Cue-induced drug craving progressively intensifies after withdrawal from self-administration
of cocaine, methamphetamine, and other drugs of abuse, a phenomenon termed incubation …
of cocaine, methamphetamine, and other drugs of abuse, a phenomenon termed incubation …
Accumbens nNOS interneurons regulate cocaine relapse
Relapse to drug use can be initiated by drug-associated cues. The intensity of cue-induced
relapse is correlated with the induction of transient synaptic potentiation (t-SP) at …
relapse is correlated with the induction of transient synaptic potentiation (t-SP) at …
Role of mGluR5 neurotransmission in reinstated cocaine‐seeking
X Wang, K Moussawi, L Knackstedt, H Shen… - Addiction …, 2013 - Wiley Online Library
In animal models of addiction, reducing glutamate stimulation of the metabotropic glutamate
receptor 5 (mGluR5) inhibits drug‐seeking. The present study used the reinstatement model …
receptor 5 (mGluR5) inhibits drug‐seeking. The present study used the reinstatement model …
Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking
LA Knackstedt, K Moussawi, R Lalumiere… - Journal of …, 2010 - Soc Neuroscience
Learning to inhibit drug seeking can be an important strategy for inhibiting relapse, and this
can be modeled by extinguishing drug seeking in response to a drug-paired context. Rats …
can be modeled by extinguishing drug seeking in response to a drug-paired context. Rats …
mGlu1 and mGlu5 modulate distinct excitatory inputs to the nucleus accumbens shell
BD Turner, JM Rook, CW Lindsley, PJ Conn… - …, 2018 - nature.com
Glutamatergic transmission in the nucleus accumbens shell (NAcSh) is a substrate for
reward learning and motivation. Metabotropic glutamate (mGlu) receptors regulate NAcSh …
reward learning and motivation. Metabotropic glutamate (mGlu) receptors regulate NAcSh …
Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking
KR Famous, V Kumaresan, G Sadri-Vakili… - Journal of …, 2008 - Soc Neuroscience
A growing body of evidence indicates that enhanced AMPA-mediated glutamate
transmission in the core of the nucleus accumbens is critically involved in cocaine priming …
transmission in the core of the nucleus accumbens is critically involved in cocaine priming …
Using metabotropic glutamate receptors to modulate cocaine's synaptic and behavioral effects: mGluR1 finds a niche
Group I metabotropic glutamate receptors (mGluR) are important modulators of excitatory
synaptic transmission and therefore potential targets for drug development. In several brain …
synaptic transmission and therefore potential targets for drug development. In several brain …
Incubation of cocaine seeking following brief cocaine experience in mice is enhanced by mGluR1 blockade
B Halbout, RE Bernardi, AC Hansson… - Journal of …, 2014 - Soc Neuroscience
The incubation of cocaine craving describes the time-dependent augmentation of cue-
induced cocaine seeking during withdrawal from prolonged cocaine self-administration and …
induced cocaine seeking during withdrawal from prolonged cocaine self-administration and …
Genetic loss of GluN2B in D1-expressing cell types enhances long-term cocaine reward and potentiation of thalamo-accumbens synapses
Transient upregulation of GluN2B-containing NMDA receptors (R) in the nucleus
accumbens (NAc) is proposed as an intermediate to long-term AMPAR plasticity associated …
accumbens (NAc) is proposed as an intermediate to long-term AMPAR plasticity associated …
Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens
Cocaine exposure induces plasticity of glutamatergic synapses of medium spiny neurons
(MSNs) in the nucleus accumbens (NAc), which has been proposed to contribute to its …
(MSNs) in the nucleus accumbens (NAc), which has been proposed to contribute to its …