Psychostimulant-induced neuroadaptations in nucleus accumbens AMPA receptor transmission
Medium spiny neurons of the nucleus accumbens serve as the interface between
corticolimbic regions that elicit and modulate motivated behaviors, including those related to …
corticolimbic regions that elicit and modulate motivated behaviors, including those related to …
Drug refraining and seeking potentiate synapses on distinct populations of accumbens medium spiny neurons
D Roberts-Wolfe, AC Bobadilla… - Journal of …, 2018 - Soc Neuroscience
Cocaine-associated cues and contexts can precipitate drug seeking in humans and in
experimental animals. Glutamatergic synapses in the core subcompartment of the nucleus …
experimental animals. Glutamatergic synapses in the core subcompartment of the nucleus …
Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens
Cocaine exposure induces plasticity of glutamatergic synapses of medium spiny neurons
(MSNs) in the nucleus accumbens (NAc), which has been proposed to contribute to its …
(MSNs) in the nucleus accumbens (NAc), which has been proposed to contribute to its …
Group I metabotropic glutamate receptor‐mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking
HD Schmidt, BA Kimmey, AC Arreola… - Addiction …, 2015 - Wiley Online Library
Emerging evidence indicates that type I metabotropic glutamate receptors (mGluRs) in the
nucleus accumbens play a critical role in cocaine seeking. The present study sought to …
nucleus accumbens play a critical role in cocaine seeking. The present study sought to …
Persistent strengthening of the prefrontal cortex–nucleus accumbens pathway during incubation of cocaine-seeking behavior
C Luís, N Cannella, R Spanagel, G Köhr - Neurobiology of learning and …, 2017 - Elsevier
High rates of relapse after prolonged abstinence are often triggered by exposure to drug-
associated cues that induce drug craving. Incubation of drug craving is a phenomenon that …
associated cues that induce drug craving. Incubation of drug craving is a phenomenon that …
mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism
Abstract Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-
administration and reinstatement of drug-seeking behavior. However, the cellular and …
administration and reinstatement of drug-seeking behavior. However, the cellular and …
Cascades of homeostatic dysregulation promote incubation of cocaine craving
In human drug users, cue-induced drug craving progressively intensifies after drug
abstinence, promoting drug relapse. This time-dependent progression of drug craving is …
abstinence, promoting drug relapse. This time-dependent progression of drug craving is …
Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc
Addictive drugs hijack mechanisms of learning and memory that normally underlie
reinforcement of natural rewards and induce synaptic plasticity of glutamatergic transmission …
reinforcement of natural rewards and induce synaptic plasticity of glutamatergic transmission …
Prelimbic cortex and ventral tegmental area modulate synaptic plasticity differentially in nucleus accumbens during cocaine-reinstated drug seeking
Addictive drug use causes long-lasting changes in synaptic strength and dendritic spine
morphology in the nucleus accumbens that might underlie the vulnerability to relapse …
morphology in the nucleus accumbens that might underlie the vulnerability to relapse …
Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory
JT Gass, MF Olive - Biological psychiatry, 2009 - Elsevier
BACKGROUND: The perseverance of the motivational salience of drug-associated
memories is an obstacle to the successful treatment of drug addiction and is often a …
memories is an obstacle to the successful treatment of drug addiction and is often a …