Genome‐wide DNA methylation profile analysis in thoracic ossification of the ligamentum flavum

T Fan, X Meng, C Sun, X Yang, G Chen… - Journal of Cellular …, 2020 - Wiley Online Library
Thoracic ossification of the ligamentum flavum (TOLF) causes serious spinal canal stenosis.
The underlying aetiology may relate to genetic and inflammatory factors. DNA methylation …

Identification of the molecular mechanism and diagnostic biomarkers in the thoracic ossification of the ligamentum flavum using metabolomics and transcriptomics

J Li, L Yu, S Guo, Y Zhao - BMC Molecular and Cell Biology, 2020 - Springer
Background To establish a metabolite fingerprint of ossification of the thoracic ligamentum
flavum (OTLF) patients using liquid chromatography-mass spectrometry (LC-MS) in …

iTRAQ quantitative proteomic study in patients with thoracic ossification of the ligamentum flavum

B Wang, Z Chen, X Meng, M Li, X Yang… - … and biophysical research …, 2017 - Elsevier
Thoracic ossification of the ligamentum flavum (TOLF) is a unique disease with ectopic
ossification, and is a major cause of thoracic spinal stenosis and myelopathy. However, the …

A transcriptome-level study identifies changing expression profiles for ossification of the ligamentum flavum of the spine

Y Han, Y Hong, L Li, T Li, Z Zhang, J Wang… - … Therapy-Nucleic Acids, 2018 - cell.com
Ossification of the ligamentum flavum (OLF) is a common spinal disorder that causes
myelopathy and radiculopathy. Non-coding RNAs (ncRNAs) are involved in numerous …

LGR5 regulates osteogenic differentiation of human thoracic ligamentum flavum cells by Wnt signalling pathway

X Yang, C Sun, X Meng, G Chen, T Fan… - Journal of Cellular …, 2022 - Wiley Online Library
Thoracic ossification of the ligamentum flavum (TOLF) is ectopic ossification of the spinal
ligaments. Histologically, the development of TOLF can be described as the process of …

Identification of crucial miRNAs and lncRNAs for ossification of ligamentum flavum

D Kong, Q Zhao, W Liu, F Wang - Molecular medicine …, 2019 - spandidos-publications.com
The present study aimed to screen crucial micro (mi) RNAs and long non‑coding (lnc) RNAs
involved in the development of ossification of ligamentum flavum (OLF) based on the miRNA …

Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration

A Ikuno, K Akeda, S Takebayashi, M Shimaoka… - PloS one, 2019 - journals.plos.org
Background Environmental and endogenous factors under genetic predisposition are
considered to initiate the human intervertebral disc (IVD) degeneration. DNA methylation is …

The involvement and possible mechanism of pro-inflammatory tumor necrosis factor alpha (TNF-α) in thoracic ossification of the ligamentum flavum

C Zhang, Z Chen, X Meng, M Li, L Zhang, A Huang - PloS one, 2017 - journals.plos.org
Thoracic ossification of the ligamentum flavum (TOLF) is characterized by ectopic bone
formation in the ligamentum flavum and is considered to be a leading cause of thoracic …

[HTML][HTML] Identification of abnormally methylated–differentially expressed genes and pathways in osteoarthritis: a comprehensive bioinformatic study

L Zheng, W Chen, G Xian, B Pan, Y Ye, M Gu… - Clinical …, 2021 - Springer
Objectives To investigate abnormally methylated–differentially expressed genes (DEGs) and
their related pathways in osteoarthritis (OA) by comprehensive bioinformatic analysis …

Genome-wide DNA methylation profiling of hip articular cartilage identifies differentially methylated loci associated with osteonecrosis of the femoral head

J Wu, Y Du, J Song, X Dang, K Wang, Y Wen, F Zhang… - Bone, 2019 - Elsevier
Objective Recent studies demonstrated a critical role of hip articular cartilage destruction in
the development of osteonecrosis of the femoral head (ONFH). The aim of this study was to …