Disappearance of fibrosis in secondary myelofibrosis after ruxolitinib treatment: new endpoint to achieve?

M Molica, A Serrao, R Saracino, I Zacheo… - Annals of …, 2014 - Springer
Dear Editor, Myelofibrosis is a myeloproliferative entity clinically characterized by
progressive anemia, bone marrow fibrosis, and extramedullary hematopoiesis with …

The JAK2 V617F tyrosine kinase mutation in myelodysplastic syndromes (MDS) developing myelofibrosis indicates the myeloproliferative nature in a subset of MDS …

K Ohyashiki, Y Aota, D Akahane, A Gotoh, K Miyazawa… - Leukemia, 2005 - nature.com
The JAK2 V617F tyrosine kinase mutation is responsible for the development of BCR/ABL-
negative chronic myeloproliferative disorders, including myelofibrosis (MF). 1–4 Kralovics et …

Higher JAK2 V617F mutant allele burden in patients with chronic myeloproliferative neoplasms is associated with a higher prevalence of chronic kidney disease and …

M Lucijanic, P Veic, I Aric, KM Tupek, E Soric… - Annals of …, 2023 - Springer
Dear Editor, Chronic kidney disease (CKD) is present in up to 25% of chronic
myeloproliferative neoplasm (MPN) patients [1–4], which is higher than in the general …

[HTML][HTML] Systematic evaluation of DNA-based quantitative-polymerase chain reaction (Q-PCR) assays to track treatment response in patients with JAK2-V617F …

JV Jovanovic, AM Vannucchi, E Lippert, EO Leibundgut… - Blood, 2011 - Elsevier
Abstract 2812 Since the discovery of the JAK2-V617F mutation, the relative level of the
mutant allele has been widely studied to gain further insights into the biology of …

Clinical and morphologic features in five post-polycythemic myelofibrosis patients treated with ruxolitinib

A Iurlo, D Cattaneo, L Boiocchi, N Orofino, E Fermo… - Annals of …, 2015 - Springer
Dear Editor, Myelofibrosis (MF), either primary (PMF) or secondary to polycythemia vera
(post-PV MF), is associated with a dismal prognosis in terms of overall survival (OS) and …

[HTML][HTML] PCR artifacts can explain the reported biallelic JAK2 mutations

R Gao, AH Zhao, Y Du, WT Ho, X Fu, ZJ Zhao - Blood Cancer Journal, 2012 - nature.com
JAK2V617F, an activation mutant form of tyrosine kinase JAK2, is found in the majority of
patients with myeloproliferative neoplasms (MPNs) including polycythemia vera (PV) …

Allele-specific wild-type blocker quantitative PCR for highly sensitive detection of rare JAK2 p. V617F point mutation in primary myelofibrosis as an appropriate tool for …

U Siebolts, T Lange, D Niederwieser… - Journal of clinical …, 2010 - jcp.bmj.com
Screening of JAK2 V617F point mutation becomes more and more important in monitoring of
JAK2 positive MPN following stem cell transplantation. In an attempt to achieve the required …

Clearance of the Janus kinase 2 (JAK2) V617F mutation after allogeneic stem cell transplantation in a patient with myelofibrosis with myeloid metaplasia

GJ Ruiz‐Argüelles, J Garcés‐Eisele… - American journal of …, 2007 - Wiley Online Library
A patient with myelofibrosis with myeloid metaplasia displaying the V617F mutation of the
JAK2 gene was given an allogeneic stem cell transplantation using a reduced‐intensity …

The prognostic impact of non‐driver gene mutations and variant allele frequency in primary myelofibrosis

A Hernández‐Sánchez… - American Journal of …, 2024 - Wiley Online Library
To the Editor: Myelofibrosis is a Philadelphia-negative chronic myeloproliferative neoplasm
(MPN) characterized by alteration of the JAK–STAT pathway, primarily through activating …

[HTML][HTML] Coexistence of BCR/ABL1-positive chronic myeloid leukemia and JAK2 V617F-mutated myelofibrosis successfully treated with dasatinib and ruxolitinib

JH Yi, HR Kim - Blood research, 2019 - ncbi.nlm.nih.gov
TO THE EDITOR: Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell
disorders characterized by the proliferation of cells of one or more of the myeloid lineages …