Both, jawless and jawed vertebrates possess three lymphocyte lineages defined by highly
diverse antigen receptors: Two T‐cell‐and one B‐cell‐like lineage. In both phylogenetic …

The mechanistic requirements of antigen recognition by T cells expressing a γδ TCR has
revealed important differences with those of αβ TCR cells and, despite impressive new data …

Despite playing critical roles in the immune response and having significant potential in
immunotherapy, γδ T cells have garnered little of the limelight. One major reason for this …

Vγ9Vδ2 T cells, a major human peripheral γδ T-cell subset, react in vitro against a wide
array of microbial agents and tumor cells. This broad reactivity pattern is conferred by non …

T cell populations exist that express distinct T cell antigen receptors (TCRs). Following
identification of the~ 13 TCR heterodimer protein complex [2, 77, 110], the genes encoding …

Mature T lymphocytes carrying the conventional αβ T cell receptor (TCR) recognize peptide
antigens in the context of MHC class I (CD8+) and MHC class II (CD4+) antigens …

Vγ9Vδ2 T cells represent a major unconventional γδ T cell subset located in the peripheral
blood of adults in humans and several non-human primates. Lymphocytes that constitute …

The predominant population of γδ T cells in human blood express a T cell receptor (TCR)
composed of a Vγ9 (Vγ2 in an alternate nomenclature) and Vδ2 domains. These cells came …

Vγ9Vδ2 cells, a major peripheral blood γδ T cell subset in adults, recognize non-peptidic
phosphorylated metabolites referred to as phosphoantigens (phosphoAg), which are …

The series of seminal articles in this book clearly illustrate the multi-functional nature of γδ T
cells. Some of the functions correlate with the tissue tropism of distinct γδ T cell subsets …