The melanocortin peptides derived from pro-opiomelanocortin (POMC) were originally
understood in terms of the biological actions of α-melanocyte-stimulating hormone (α-MSH) …

The peptide products of the pro-opiomelanocortin (POMC) gene have established roles in
the control of physiological processes as diverse as adrenal steroidogenesis, skin …

The melanocortins are derived from proopiomelanocortin (POMC) and include three forms of
melanocyte-stimulating hormone (α-, β-, γ-, MSH) and adrenocorticotropic hormone. α-MSH …

Proopiomelanocortin (POMC) is expressed in the arcuate nucleus of the hypothalamus
(ARC) and the commissural nucleus of the solitary tract (cNTS). Post‐translational …

Proopiomelanocortin (POMC) is best known to the clinical endocrinologist as the precursor
for pituitary ACTH, which is essential for maintaining adrenal cortical function. The most well …

The melanocortins, a family of peptides produced from the post-translational processing of
pro-opiomelanocortin (POMC), regulate ingestive behavior and energy expenditure. Loss of …

The importance of the central melanocortin system in the regulation of energy balance is
highlighted by studies in transgenic animals and humans with defects in this system. Mice …

Functional disruption of either MC3R or MC4R results in obesity, implicating both in the
control of energy homeostasis. The ligands for these receptors are derived from the …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Summary The melanocortin-4 receptor (MC4R) plays a critical role in the control of energy
balance. Of its two pro-opiomelanocortin (POMC)-derived ligands, α-and β-MSH, the …