Unveiling complexity and multipotentiality of early heart fields
Rationale: Extraembryonic tissues, including the yolk sac and placenta, and the heart within
the embryo, work to provide crucial nutrients to the embryo. The association of congenital …
the embryo, work to provide crucial nutrients to the embryo. The association of congenital …
[HTML][HTML] Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak
K Ivanovitch, P Soro-Barrio, P Chakravarty… - PLoS …, 2021 - journals.plos.org
The heart develops from 2 sources of mesoderm progenitors, the first and second heart field
(FHF and SHF). Using a single-cell transcriptomic assay combined with genetic lineage …
(FHF and SHF). Using a single-cell transcriptomic assay combined with genetic lineage …
The heart field transcriptional landscape at single-cell resolution
RG Kelly - Developmental Cell, 2023 - cell.com
Organogenesis requires the orchestrated development of multiple cell lineages that
converge, interact, and specialize to generate coherent functional structures, exemplified by …
converge, interact, and specialize to generate coherent functional structures, exemplified by …
Embryonic heart progenitors and cardiogenesis
T Brade, LS Pane, A Moretti… - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
The mammalian heart is a highly specialized organ, comprised of many different cell types
arising from distinct embryonic progenitor populations during cardiogenesis. Three …
arising from distinct embryonic progenitor populations during cardiogenesis. Three …
Early patterning and specification of cardiac progenitors in gastrulating mesoderm
Mammalian heart development requires precise allocation of cardiac progenitors. The
existence of a multipotent progenitor for all anatomic and cellular components of the heart …
existence of a multipotent progenitor for all anatomic and cellular components of the heart …
Cardiac lineages
T Mikawa - Heart development, 1999 - Elsevier
Publisher Summary To understand the molecular mechanisms that govern sequentially
programmed development and integration of these subcardiac components during heart …
programmed development and integration of these subcardiac components during heart …
Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development
F Lescroart, S Chabab, X Lin, S Rulands… - Nature cell …, 2014 - nature.com
Cardiac development arises from two sources of mesoderm progenitors, the first heart field
(FHF) and the second (SHF). Mesp1 has been proposed to mark the most primitive …
(FHF) and the second (SHF). Mesp1 has been proposed to mark the most primitive …
Graded mesoderm assembly governs cell fate and morphogenesis of the early mammalian heart
MH Dominguez, AL Krup, JM Muncie, BG Bruneau - Cell, 2023 - cell.com
Using four-dimensional whole-embryo light sheet imaging with improved and accessible
computational tools, we longitudinally reconstruct early murine cardiac development at …
computational tools, we longitudinally reconstruct early murine cardiac development at …
[PDF][PDF] Modeling human multi-lineage heart field development with pluripotent stem cells
The cardiomyocyte (CM) subtypes in the mammalian heart derive from distinct lineages
known as the first heart field (FHF), the anterior second heart field (aSHF), and the posterior …
known as the first heart field (FHF), the anterior second heart field (aSHF), and the posterior …
The heart endocardium is derived from vascular endothelial progenitors
M Milgrom-Hoffman, Z Harrelson, N Ferrara… - …, 2011 - journals.biologists.com
The embryonic heart is composed of two cell layers: the myocardium, which contributes to
cardiac muscle tissue, and the endocardium, which covers the inner lumen of the heart …
cardiac muscle tissue, and the endocardium, which covers the inner lumen of the heart …