Matrix rigidity has important effects on cell behavior and is increased during liver fibrosis;
however, its effect on primary hepatocyte function is unknown. We hypothesized that …

Extracellular matrix (ECM) rigidity has important effects on cell behaviors and increases
sharply in liver fibrosis and cirrhosis. Hepatic blood flow is essential in maintaining …

Background & Aims Liver stiffness is increased in advanced chronic liver disease (ACLD)
and accurately predicts prognosis in this population. Recent data suggest that extracellular …

The fibrogenic wound-healing response in liver increases stiffness. Stiffness
mechanotransduction, in turn, amplifies fibrogenesis. Here, we aimed to understand the …

Matrix stiffness (resistance to deformation), one of the many mechanical forces acting on
cells, is increasingly appreciated as an important mediator of cell behavior. It regulates cell …

Tissues including liver stiffen and acquire more extracellular matrix with fibrosis. The
relationship between matrix content and stiffness, however, is non-linear, and stiffness is …

Tissue and matrix stiffness affect cell properties during morphogenesis, cell growth,
differentiation, and migration and are altered in the tissue remodeling following injury and …

Liver fibrosis occurs as a consequence of chronic injuries from viral infections, metabolic
disorders, and alcohol abuse. Fibrotic liver microenvironment (LME) is characterized by …

Background Increased liver stiffness exerts a detrimental role in driving hepatocellular
carcinoma (HCC) malignancy and progression, and indicates a high risk of unfavorable …

The hallmark of liver fibrosis is excessive extracellular matrix (ECM) synthesis and
deposition that improve liver matrix remodeling and stiffening. Increased matrix stiffness is …