Fibrosis is characterized by extracellular matrix (ECM) remodeling and stiffening. However,
the functional contribution of tissue stiffening to noncancer pathogenesis remains largely …

Background & Aims Liver sinusoidal endothelial cells (LSECs) are ideally situated to sense
stiffness and generate angiocrine programs that potentially regulate liver fibrosis and portal …

Chronic liver diseases, such as fibrosis and cancer, lead to a rigid or stiff liver because of
perpetual activation of hepatic stellate cells or portal fibroblasts into matrix-producing …

Cell spreading is correlated with changes in important cell functions including DNA
synthesis, motility, and differentiation. Spreading is accompanied by a complex …

The differentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in liver
fibrosis. Due to the local stiffening of the extracellular matrix (ECM) during fibrosis, it is of …

Background and aims Hepatocyte nuclear factor 4α (HNF4α) is a central transcriptional
regulator of hepatocyte differentiation and function. The aim of this study was to evaluate the …

The myofibroblastic differentiation of hepatic stellate cells (HSC) is a critical event in liver
fibrosis and is part of the final common pathway to cirrhosis in chronic liver disease from all …

The extracellular matrix (ECM) presents an evolving set of mechanical cues to resident cells.
We developed methacrylated hyaluronic acid (MeHA) hydrogels containing both stable and …

Hepatocellular carcinoma (HCC) was usually coupled with increased stiffness of the
extracellular matrix (ECM) and elevated level of transforming growth factor-β1 (TGF-β1) …

Independent of their etiology, all chronic liver diseases ultimately lead to liver cirrhosis,
which is a major health problem worldwide. The underlying molecular mechanisms are still …