In the liver, hepatocytes are exposed to a large array of stimuli that shape hepatic
phenotype. This in vivo microenvironment is lost when hepatocytes are cultured in standard …

Hepatocytes are critical for the maintenance of liver homeostasis, but its involvement in
hepatic fibrogenesis remains elusive. Hepatocyte nuclear factor 1α (HNF1α) is a liver …

Background & Aims Mechanical forces contribute to portal hypertension (PHTN) and
fibrogenesis. We investigated the mechanisms by which forces are transduced by liver …

Liver fibrosis is currently staged using needle biopsy, a highly invasive procedure with a
number of disadvantages. Measurement of liver stiffness changes that accompany …

Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes
in extracellular matrix (ECM) mechanics contribute to cancer development 1, 2, and …

A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …

Hepatic fibrosis is associated with an overproduction of matrix proteins and a pathological
increase of liver stiffness. Noninvasive magnetic resonance (MR) quantification of matrix can …

The role of pathological angiogenesis on liver fibrogenesis is still unknown. Here, we
developed fibrotic microniches (FμNs) that recapitulate the interaction of liver sinusoid …

Decellularization, a technique used in liver regenerative medicine, is the removal of all the
cellular components from a tissue or organ, leaving behind an intact structure of extracellular …

Liver fibrosis is the result of a deregulated wound healing process characterized by the
excessive deposition of extracellular matrix. Hepatic stellate cells (HSCs), which are …