Tissue fibrosis contributes to nearly half of all deaths in the developed world and is
characterized by progressive matrix stiffening. Despite this, nearly all in vitro disease models …

Chronic liver disease is a world‐wide problem that causes progressive hepatic fibrosis as a
hallmark of progressive injury. At present, the gold standard for diagnosing hepatic fibrosis is …

Mechanobiology is a domain of interdisciplinary research that aims to explore the impact of
physical force, applied externally or internally, on cell and tissue function, including …

Liver fibrosis is end-stage liver disease that can be rescued. If irritation continues due to viral
infection, schistosomiasis and alcoholism, liver fibrosis can progress to liver cirrhosis and …

The noninvasive quantitation of liver stiffness (LS) by ultrasound based transient
elastography using FibroScan® has revolutionized the diagnosis of liver diseases, namely …

Increased stiffness of solid tissues has long been recognized as a diagnostic feature of
several pathologies, most notably malignant diseases. In fact, it is now well established that …

In many cell types, several cellular processes, such as differentiation of stem/precursor cells,
maintenance of differentiated phenotype, motility, adhesion, growth, and survival, strictly …

The cellular microenvironment plays a critical role in cell differentiation, proliferation,
migration, and homeostasis. Recent studies have shown the importance of substrate …

Background & Aims In vitro, cell function can be potently regulated by the mechanical
properties of cells and of their microenvironment. Cells measure these features by …

Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks
that regulate the deposition of extracellular matrix. This cascade of responses drives the …