Background Multiple sclerosis (MS) is a complex autoimmune disorder characterized by
neurologic dysfunction. The symptoms worsen as the disease progresses to the relapsing …

Multiple sclerosis (MS) is a multifocal demyelinating disease of the central nervous system
pathologically characterized by lesions of infiltrating macrophages and T cells. Multiple lines …

T lymphocytes play a central role in the pathogenesis of multiple sclerosis (MS)(Zhang et al.,
1992). Both CD4+ and CD8+ T cells have been demonstrated in MS lesions, with CD4+ T …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterized by focal demyelination patches associated with inflammatory infiltrates …

Traditionally, autoimmune pathogeneses have been attributed to CD4+ T lymphocytes, as in
multiple sclerosis (MS), rheumatoid arthritis, type 1 diabetes mellitus, and/or to B …

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system in
which destruction of myelin and nerve axons has been shown to be mediated by immune …

The cause of multiple sclerosis (MS) is unknown, but an immunopathological process with
both endogenous and exogenous factors contributing to disease seems likely. Considerable …

Background Multiple sclerosis-associated genetic variants indicate that the adaptive
immune system plays an important role in the risk of developing multiple sclerosis. It is …

Activated myelin-specific T cells are thought to mediate inflammatory tissue damage in
multiple sclerosis (MS). Applying a large panel of myelin antigens, we demonstrate the direct …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. Although the precise etiology of MS remains unclear, CD4+ T cells have been …