Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1
The transcription factor hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tumour
growth and progression, and HIF-1 is regulated through a number of signalling pathways …
growth and progression, and HIF-1 is regulated through a number of signalling pathways …
eIF2α Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1α
AI Papadakis, E Paraskeva, P Peidis, H Muaddi, S Li… - Cancer research, 2010 - AACR
Hypoxia within the tumor microenvironment promotes angiogenesis, metabolic
reprogramming, and tumor progression. In addition to activating hypoxia-inducible factor-1α …
reprogramming, and tumor progression. In addition to activating hypoxia-inducible factor-1α …
Hypoxia-inducible factor-1α expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas
EH Gort, AJ Groot, TLP Derks Van De Ven… - Oncogene, 2006 - nature.com
Abstract Hypoxia-inducible factor-1 alpha (HIF-1α) is the regulatory subunit of the
heterodimeric transcription factor HIF-1 and the key factor in cellular response to low oxygen …
heterodimeric transcription factor HIF-1 and the key factor in cellular response to low oxygen …
Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1α expression
JI Bárdos, NM Chau, M Ashcroft - Molecular and cellular biology, 2004 - Taylor & Francis
The hypoxia-inducible factor 1 (HIF-1) transcriptional complex is regulated by cellular
oxygen levels and growth factors. The phosphoinosotide 3-kinase (PI-3K)-Akt/protein kinase …
oxygen levels and growth factors. The phosphoinosotide 3-kinase (PI-3K)-Akt/protein kinase …
MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300
Hypoxia-inducible factors (HIF) are a family of heterodimeric transcriptional regulators that
play pivotal roles in the regulation of cellular utilization of oxygen and glucose and are …
play pivotal roles in the regulation of cellular utilization of oxygen and glucose and are …
Kinases as upstream regulators of the HIF system: their emerging potential as anti-cancer drug targets
EY Dimova, C Michiels… - Current pharmaceutical …, 2009 - ingentaconnect.com
The hypoxia-inducible factor-1 (HIF-1) is a key regulator in the mammalian response to
oxygen deficiency under both physiological and pathological conditions such as cancer. A …
oxygen deficiency under both physiological and pathological conditions such as cancer. A …
Hypoxia‐inducible factor‐1 and oncogenic signalling
JI Bárdos, M Ashcroft - Bioessays, 2004 - Wiley Online Library
An understanding of underlying mechanisms involved in the activation of HIF‐1 in response
to both hypoxic stress and oncogenic signals has important implications for how these …
to both hypoxic stress and oncogenic signals has important implications for how these …
[HTML][HTML] Transcriptional regulation of hypoxia-inducible factor 1α by HIPK2 suggests a novel mechanism to restrain tumor growth
L Nardinocchi, R Puca, D Guidolin, AS Belloni… - … et Biophysica Acta (BBA …, 2009 - Elsevier
HIPK2 has been implicated in restraining tumor progression by more than one mechanism,
involving both its catalytic and transcriptional co-repressor functions. Starting from the …
involving both its catalytic and transcriptional co-repressor functions. Starting from the …
Negative and positive regulation of HIF-1: a complex network
JI Bárdos, M Ashcroft - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2005 - Elsevier
Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic
response in eukaryotic cells, regulating the expression of a myriad of genes involved in …
response in eukaryotic cells, regulating the expression of a myriad of genes involved in …
Molecular responses to hypoxia-inducible factor 1α and beyond
J Brocato, Y Chervona, M Costa - Molecular pharmacology, 2014 - ASPET
Cellular response to changes in oxygen tension during normal development or pathologic
processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen-sensitive …
processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen-sensitive …