The transcription factor hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tumour
growth and progression, and HIF-1 is regulated through a number of signalling pathways …

Hypoxia within the tumor microenvironment promotes angiogenesis, metabolic
reprogramming, and tumor progression. In addition to activating hypoxia-inducible factor-1α …

Abstract Hypoxia-inducible factor-1 alpha (HIF-1α) is the regulatory subunit of the
heterodimeric transcription factor HIF-1 and the key factor in cellular response to low oxygen …

The hypoxia-inducible factor 1 (HIF-1) transcriptional complex is regulated by cellular
oxygen levels and growth factors. The phosphoinosotide 3-kinase (PI-3K)-Akt/protein kinase …

Hypoxia-inducible factors (HIF) are a family of heterodimeric transcriptional regulators that
play pivotal roles in the regulation of cellular utilization of oxygen and glucose and are …

The hypoxia-inducible factor-1 (HIF-1) is a key regulator in the mammalian response to
oxygen deficiency under both physiological and pathological conditions such as cancer. A …

An understanding of underlying mechanisms involved in the activation of HIF‐1 in response
to both hypoxic stress and oncogenic signals has important implications for how these …

HIPK2 has been implicated in restraining tumor progression by more than one mechanism,
involving both its catalytic and transcriptional co-repressor functions. Starting from the …

Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic
response in eukaryotic cells, regulating the expression of a myriad of genes involved in …

Cellular response to changes in oxygen tension during normal development or pathologic
processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen-sensitive …