Arcuate nucleus neurons are known to be responsive to a wide array of hormones and
nutrients, including leptin, insulin, gonadal steroids and glucose. In addition to potential …

Neurons of the arcuate nucleus of the hypothalamus (ARH) appear to be sites of
convergence of central and peripheral signals of energy stores, and profoundly modulate …

The arcuate nucleus (ARC) of the hypothalamus is particularly regarded as a critical platform
that integrates circulating signals of hunger and satiety reflecting energy stores and nutrient …

Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

The importance of the central melanocortin system in the regulation of energy balance is
highlighted by studies in transgenic animals and humans with defects in this system. Mice …

Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores.
POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating …

The central melanocortin system plays a key role in the regulation of energy homeostasis.
Neurons containing the peptide precursor proopiomelanocortin (POMC) are found at two …

The arcuate nucleus (ARC) is crucial for the maintenance of energy homeostasis as an
integrator of long-and short-term hunger and satiety signals. The expression of receptors for …

A little more than a decade ago, the molecular basis of the lipostat was largely unknown. At
that time, many laboratories were at work attempting to clone the genes encoding the …

The brain hypothalamus coordinates extra-hypothalamic regions to maintain energy
homeostasis through the regulation of food intake and energy expenditure. A number of …