Interferon (IFN) is thought to play an important role in the vertebrate immune system, but
systemic knowledge of IFN evolution has yet to be elucidated. To evaluate the phylogenic …

Type I interferons (IFNs) include the IFN-α family of subtypes, IFN-β, IFN-ω, IFN-τ, IFN-κ, IFN-
λ, and IFN-ζ. IFN genes lack introns and encode secretory signal peptide sequences that are …

Since their discovery about 50 years ago [1], the interferons (IFNs) have been extensively
studied, they are used clinically and their multiple functions are being elucidated at the …

In this study, we provide the first comprehensive annotation of the entire family of canine
interferons (IFNs). Canine IFN-ɛ (IFNE), IFN-κ (IFNK), and IFN-λ (IFNL) were discovered for …

Phylogenetic analysis of type I interferon (IFN) from birds and mammals strongly supported
the hypothesis that the gene duplication giving rise to the α and β families of mammalian IFN …

A phylogenetic analysis of mammalian type I interferon (IFN) genes showed:(1) that the
three main subfamilies of these genes in mammals (IFN-β, IFN-α, and IFN-ω) diverged after …

The type III interferon (IFN-λ) family includes 4 IFN-λ subtypes in man. In the mouse, only the
genes coding for IFN-λ2 and-λ3 are present. Unlike mouse and human type I IFNs (IFN-α/β) …

Mouse and human genomes carry more than a dozen genes coding for closely related
alpha interferon (IFN-α) subtypes. IFN-α, as well as IFN-β, IFN-κ, IFN-ε, and limitin, are …

Abstract Background The Type I interferons (IFN) have major roles in the innate immune
response to viruses, a function that is believed to have led to expansion in the number and …

The human interferon α2 (IFNα2) was the first highly active IFN subtype to be cloned in the
early eighties. It was also the first IFN and the first cytokine to be produced and …