Potential epigenetic therapeutics for atherosclerosis treatment

I Nicorescu, GM Dallinga, MPJ de Winther, ESG Stroes… - Atherosclerosis, 2019 - Elsevier
Notwithstanding the intense efforts into the understanding and prevention of cardiovascular
disease (CVD), its complex pathology remains the leading cause of mortality worldwide. The …

The involvement of epigenetics in vascular disease development

L Elia, G Condorelli - The international journal of biochemistry & cell biology, 2019 - Elsevier
Cardiovascular diseases are a major cause of death and disability. Despite enormous
progress in diagnosis, prevention, and treatment over the years, the incidence of this group …

DNA methylation and histone post-translational modifications in atherosclerosis and a novel perspective for epigenetic therapy

L Zhang, C Xia, Y Yang, F Sun, Y Zhang… - Cell Communication and …, 2023 - Springer
Atherosclerosis, which is a vascular pathology characterized by inflammation and plaque
build-up within arterial vessel walls, acts as the important cause of most cardiovascular …

Epigenetic associations in relation to cardiovascular prevention and therapeutics

S Voelter-Mahlknecht - Clinical epigenetics, 2016 - Springer
Cardiovascular diseases (CVD) increasingly burden societies with vast financial and health
care problems. Therefore, the importance of improving preventive and therapeutic measures …

Epigenetics and vascular diseases

MS Stratton, FM Farina, L Elia - Journal of molecular and cellular cardiology, 2019 - Elsevier
Cardiovascular disease remains the number one cause of death and disability worldwide
despite significant improvements in diagnosis, prevention, and early intervention efforts …

Atherosclerosis is an epigenetic disease

S Xu, J Pelisek, ZG Jin - Trends in Endocrinology & Metabolism, 2018 - cell.com
Atherosclerosis is a chronic inflammatory and lipid-depository disease that eventually leads
to acute cardiovascular events. Emerging evidence supports that epigenetic processes such …

Treatment of cardiovascular pathology with epigenetically active agents: Focus on natural and synthetic inhibitors of DNA methylation and histone deacetylation

DA Chistiakov, AN Orekhov, YV Bobryshev - International Journal of …, 2017 - Elsevier
Cardiovascular disease (CVD) retains a leadership as a major cause of human death
worldwide. Although a substantial progress was attained in the development of …

Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials

Y Shi, H Zhang, S Huang, L Yin, F Wang… - … and Targeted Therapy, 2022 - nature.com
Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

[HTML][HTML] Epigenetics in atherosclerosis: a clinical perspective

BK Zhang, X Lai, S Jia - Discovery medicine, 2015 - discoverymedicine.com
Significant progress has been made in understanding in the pathogenesis of
atherosclerosis. Nevertheless, atherosclerosis remains a great threat to human health …

Epigenetic reprogramming in atherosclerosis

V Grimaldi, MT Vietri, C Schiano, A Picascia… - Current atherosclerosis …, 2015 - Springer
Recent data support the involvement of epigenetic alterations in the pathogenesis of
atherosclerosis. The most widely investigated epigenetic mechanism is DNA methylation …