The central nervous system (CNS) is capable of gathering information on the body's
nutritional state and it implements appropriate behavioral and metabolic responses to …

The incidences of both obesity and type 2 diabetes mellitus are rising at epidemic
proportions. Despite this, the balance between caloric intake and expenditure is …

This review describes the product of the 3‐day International Association for the Study of
Obesity (IASO) Stock Conference held in March 2004 and sponsored by Abbott …

Growing evidence implicates the brain in the regulation of both immediate fuel availability
(for example, circulating glucose) and long-term energy stores (that is, adipose tissue mass) …

Selective regions of the brain, including the hypothalamus, are capable of gathering
information on the body's nutritional status in order to implement appropriate behavioral and …

The neuroendocrine system governs essential survival and homeostatic functions. For
example, growth is needed for development, thermoregulation maintains optimal core …

The essential role of the brain in maintaining energy homeostasis has motivated the drive to
define the neural circuitry that integrates external and internal stimuli to enact appropriate …

Individual cells must carefully regulate their energy flux to ensure nutrient levels are
adequate to maintain normal cellular activity. The same principle holds in multicellular …

The 'obesity epidemic'represents a major global socioeconomic burden that urgently calls
for a better understanding of the underlying causes of increased weight gain and its …

Nutrient sensitive neurons (glucose and fatty acids, FA) are present in both the
hypothalamus and the brainstem and play a key role in nervous control of energy …