Islet transplantation (ITx) is an emerging and promising therapy for patients with
uncontrolled type 1 diabetes. The islet isolation and purification processes require exposure …

Islet transplantation is emerging as a treatment option for selected patients with type 1
diabetes. Inconsistent isolation, purification, and recovery of large numbers of high-quality …

INTRODUCTION: Despite significant advances, widespread applicability of islet cell
transplantation remains elusive. Refinement of current islet isolation protocols may improve …

Islets were selectively isolated from rat pancreatic digests using magnetic microspheres
coated with anti‐islet monoclonal antibodies. The isolation process was optimized as a …

Purification of islets based on the physical differences in density between exocrine and islet
tissue reduces islet yields and remains one of the factors limiting islet transplantation …

Immunomagnetic cell separation has been shown to be a highly attractive alternative to
density-dependent methods for islet purification. There are two types of beads, magnetic …

Because successful human islet transplantation requires large quantities of viable islets that
must be separated from the highly immunogenic exocrine tissue and because handpicking …

A central step within the human islet isolation process is the separation of islets from
contaminating exocrine tissue utilizing linear, continuous density gradients manufactured by …

Magnetic isolation is a promising method for separating and concentrating pancreatic islets
of Langerhans for transplantation in Type 1 diabetes patients. We are developing a …

Background Islet transplantation (Tx) represents the most promising therapy to restore
normoglycemia in type 1 diabetes (T1D) patients to date. As significant islet loss has been …